Highway 10 is a provincial paved undivided highway in the Canadian province of Saskatchewan. It runs from Highway 1 near Balgonie until it transitions into PTH 5 at the Manitoba border. Highway 10 is about 225 km (140 mi) long. It passes through Fort Qu'Appelle, Balcarres, Melville, and Yorkton. It intersects Highway 1 and Highway 16.

The highway is a component of Canada's National Highway System. Between Highway 1 the intersection with Highway 9 / Highway 16 concurrency in Yorkton, it is designated as a Core Route.

The Melville–Yorkton section of Highway 10 used to go through Willowbrook; in the 1960s Highway 10 was realigned to a more direct route with the bypassed section becoming part of Highway 47 and Highway 52.

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  Echo Valley Scenic Route Hwy 10
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  Scenic Route
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  Adopt a Highway along Hwy 10.

From west to east:

Rural municipality	Location	km	mi	Destinations	Notes
Edenwold No. 158	Balgonie	0.0	0.0	Highway 1 (TCH) west – Regina	Interchange; eastbound exit and westbound entrance
South Qu'Appelle No. 157	Edgeley	24.5	15.2	Highway 364 west – Edenwold
North Qu'Appelle No. 187	​	33.6	20.9	Highway 210 north – Echo Valley Provincial Park
	​	35.6	22.1	Highway 35 south – Qu'Appelle, Weyburn	West end of Hwy 35 concurrency
	Fort Qu'Appelle	46.0	28.6	Highway 35 north to Highway 22 – Wadena To Highway 56 – Fort San, Indian Head To Highway 210 south – Echo Valley Provincial Park	East end of Hwy 35 concurrency; Hwy 56 passes underneath Hwy 10 east of intersection
Abernethy No. 186	Balcarres	63.8	39.6	Highway 310 north – Ituna Highway 619 south – Indian Head
	​	71.9	44.7	Highway 22 east – Abernethy, Lemberg
	​	88.2	54.8	Highway 617 – Wolseley, Goodeve	West of Duff
Stanley No. 215	​	109.1	67.8	Highway 618 south
City of Melville		117.1	72.8	Highway 47 south – Grenfell, Estevan Highway 740 west – Westview	West end of Hwy 47 concurrency
		118.0	73.3	Highway 15 (3rd Avenue W) – Ituna, Bredenbury
		119.8	74.4	Highway 47 north (Queen Street) – Springside	East end of Hwy 47 concurrency
Cana No. 214	No major junctions
Orkney No. 244	No major junctions
City of Yorkton		155.8	96.8	Highway 10A east to Highway 52 – City Centre	Hwy 10 branches east
		159.7	99.2	Highway 9 south – Whitewood Highway 16 (TCH/YH) east – Winnipeg	Hwy 10 branches north; west end of Hwy 9 / Hwy 16 concurrence
		161.4	100.3	Highway 10A west / Highway 16A (TCH) west (Broadway Street) to Highway 52 – City Centre Highway 16 (TCH/YH) west / Highway 9 north – Canora, Saskatoon	Hwy 10 branches east; east end of Hwy 9 / Hwy 16 concurrence
Wallace No. 243	Tonkin	174.3	108.3	Highway 637 south – Saltcoats	West end of Hwy 637 concurrency
	​	179.2	111.3	Highway 637 north – Rhein	East end of Hwy 637 concurrency
Calder No. 241	Wroxton	200.3	124.5	Highway 8 north – Kamsack Highway 80 south – Churchbridge, Esterhazy	West end of Hwy 8 concurrency
	​	210.1	130.6	Calder access road
	​	220.0	136.7	Highway 8 south – MacNutt, Langenburg	East end of Hwy 8 concurrency
	​	221.9	137.9	Highway 369 north – Togo
	​	225.1	139.9	PR 482 south – Dropmore, Shellmouth, Asessippi Provincial Park	Saskatchewan–Manitoba border
				PTH 5 east – Roblin, Dauphin	Continuation into Manitoba
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access       Route transition

Highway 10A
Location	Yorkton
Length	5.0 km (3.1 mi)

Highway 10A is a highway in the Canadian province of Saskatchewan serving the city of Yorkton. It runs from Highway 10 at the city's southwestern limits to Highway 16 / Highway 9 / Highway 10. Like most alternate routes, it was the original configuration for Highway 10 through Yorkton.

The highway travels northeast for approximately 2 km (1 mi) from Highway 10 (Queen Street) to Highway 52, where it travels east along Broadway Street. At Gladstone Avenue, Highway 16A joins Broadway Street, and the two highways run concurrently to its eastern terminus as Highway 16 / Highway 9 / Highway 10. Highway 10 continues east along Broadway Street.

Highway 10A is about 5 km (3 mi) long.

From west to east. The entire route is in Yorkton.

km	mi	Destinations	Notes
0.0	0.0	Highway 10 (Queen Street) – Regina, Melville, Dauphin	Hwy 10A western terminus
1.9	1.2	Broadway Street (Highway 52 west) – Ituna	Hwy 10A follows Broadway Street
3.2	2.0	Gladstone Avenue (Highway 16A (TCH) west) – Saskatoon	West end of Hwy 16A concurrency
5.0	3.1	Highway 16 (TCH) / Highway 9 / Highway 10 west – Saskatoon, Canora, Whitewood, Winnipeg Broadway Street (Highway 10 east) – Dauphin	Hwy 10A / Hwy 16A eastern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• Transportation in Saskatchewan
• Roads in Saskatchewan