Sepilok Orangutan Rehabilitation Centre is located about 25 kilometres west of Sandakan in the state of Sabah, Malaysia.

The centre opened in 1964 as the first official orangutan rehabilitation project for rescued orphaned baby orangutans from logging sites, plantations, illegal hunting or kept as pets. The orphaned orangutans are trained to survive again in the wild and are released as soon as they are ready. The sanctuary is located within the Kabili-Sepilok Forest Reserve which covers an area of 4,294 ha (10,610 acres), much of which is virgin rainforest. The reserve has been designated an Important Bird Area by BirdLife International. Today around 60 to 80 orangutans are living free in the reserve.

The activities of the centre have featured in television series including "Paul O'Grady's Animal Orphans" and Animal Planet's "Meet the Orangutans".

In October 2014 the centre opened a section where visitors can view the nursery area where the younger Orangutans first learn to be outside and play on a large climbing frame. This consists of 2 large indoor seating areas (one with air conditioning and one with fans only) with a large window that overlooks the play area.

• Among The Great Apes With Michelle Yeoh (Documentary about the Sepilok Orang Utan Sanctuary)

• Orang Utan and other wildlife in Sepilok rainforest reserve.
• Sepilok Orang Utan Rehabilitation Centre
• Kan Yaw Chong (8 January 2023). "Historic Sepilok Jazz Festival to help turtles". Daily Express Malaysia. Retrieved 26 January 2023.

5°51′54″N 117°56′58″E / 5.86501°N 117.94939°E / 5.86501; 117.94939