Sepulveda station is a station on the G Line of the Los Angeles Metro Busway system. It is named after nearby Sepulveda Boulevard, which travels north-south and crosses the east-west busway route. Unique among G Line stations, Sepulveda's platforms are not located at the cross street, but rather about a block west of it. The station is in the Van Nuys neighborhood of the City of Los Angeles, in the central San Fernando Valley.

Various development proposals have been considered for the excess station parking and adjacent commercial parcels between Sepulveda Boulevard on the east, the transit station on the south, Interstate 405 on the west, and the Victory Park neighborhood to the north. A comprehensive study, including conceptual land usage strategies, was prepared for LA Metro by students of the UCLA Department of Urban Planning in mid-2010. Subsequently, conceptual development guidelines for the site were prepared by Metro.

Thus far, a development project including an LA Fitness is built on land formerly housing a Wickes Furniture building. Between December 2011 and February 2012, the former Wickes Furniture building was demolished for this project. By October 2012, the LADWP has put up new wooden and metal power poles along Sepulveda Blvd next to the project. The LA Fitness building was built and opened to the public in March 2013.

During the 2028 Summer Olympics, the station will serve spectators traveling to and from events at the Sepulveda Dam.

Initially scheduled for fall 2019 or spring 2020, Metro announced their intent to grade separate the G Line over Sepulveda Boulevard. LADWP installed new power poles for undergrounding the existing power lines at the intersection before the construction of the bridge's framework. These plans were delayed due to lack of funds from Measure M. The grade separation viaduct began preliminary work between Woodman station and Sepulveda in 2025.

A new transfer to the Sepulveda Transit Corridor is included in four of the five alternatives proposed as part of that project, allowing a transfer connection to the E Line at Expo/Sepulveda station and East San Fernando Valley Light Rail Transit Project at Van Nuys station.

G Line buses run 24 hours a day. Buses operate every eight minutes during peak hours on weekdays. They operate every ten minutes during the daytime on weekdays and most of the day on weekends. Night service on all days is every 20 minutes.

As of January 19, 2025, the following connections are available:

• Los Angeles Metro Bus: 237

The platform features a painting that shows a pre-Columbian glyph and a map of the monarch butterfly's migratory path.

Media related to Sepulveda (Los Angeles Metro station) at Wikimedia Commons