Serpelice [sɛrpɛˈlit͡sɛ] is a village in the administrative district of Gmina Sarnaki, within Łosice County, Masovian Voivodeship, in east-central Poland. It lies approximately 12 kilometres (7 mi) east of Sarnaki, 24 km (15 mi) east of Łosice, and 140 km (87 mi) east of Warsaw.

The well known person who comes from Serpelice is Bishop Antoni Pacyfik Dydycz.

The village has a wooden church, built in 1947, by the Order of Friars Minor Capuchin, who also have a monastery in the village.