Serre di Rapolano is a frazione in the comune of Rapolano Terme in the province of Siena, Tuscany, Italy.

It is located on a hill midway between the valleys of the Sentino and Ombrone rivers. Among the prominent buildings are: *Palazzo Gori Martini- 19th-century neo-gothic white marble palace

• Chiesa della Compagnia di Santa Caterina della Misericordia - small oratory with frescoes by Sebastiano Follia and canvases by Astolfo Petrazzi
• Castello di Modanella
• Pieve di Sant'Andreino alle Cave
• Pieve dei Santi Andrea e Lorenzo