Sierra de Guadalupe [ˈsjera ðe ɣwaðaˈlupe] is a station on Line 1 of the Madrid Metro. It is located in fare Zone A.

The station opened on 3 March 1999.

The station is adjacent to Cercanías Madrid's Vallecas station, which is served by the C-2, C-7, and C-8 commuter rail lines.

The station is named for the calle Sierra de Guadalupe, named in turn for the Sierra de Guadalupe mountains.