Simpson's College, also known as Simpson's College Museum, was a historic school building located at Graham, Nodaway County, Missouri. It was built about 1860, and is a one-story, rectangular frame building, measuring approximately 20 feet by 28 feet. A school occupied the building until 1869, after which it became a private residence. The structure was demolished in 2009.

It was listed on the National Register of Historic Places in 1978.