Herzele (Dutch pronunciation: [ˈɦɛrzeːlə]) is a municipality located in the Belgian province of East Flanders in the Denderstreek. The municipality comprises the villages of Borsbeke [nl], Herzele proper, Hillegem [nl], Ressegem [nl], Sint-Antelinks [nl], Sint-Lievens-Esse [nl], Steenhuize-Wijnhuize [nl] and Woubrechtegem [nl]. In 2021, Herzele had a total population of 18,414. The total area is 47.40 km. The current mayor of Herzele is Johan Van Tittelboom, from the Open Flemish Liberals and Democrats party.

Herzele is crossed by two brooks, the Molenbeek in Borsbeke, Herzele, Ressegem, and Hillegem, as well as the Molenbeek-Ter Erpenbeek in Herzele, Sint-Lievens-Esse, Woubrechtegem, and Ressegem.