Siracusaville is a census-designated place (CDP) in St. Mary Parish, Louisiana, United States. The population was 422 at the 2010 census. It is part of the Morgan City Micropolitan Statistical Area.

Siracusaville is located at 29°41′13″N 91°8′53″W / 29.68694°N 91.14806°W / 29.68694; -91.14806 (29.68715, -91.14186), adjacent to the eastern border of Morgan City. Louisiana State Route 182 is an east-west road that passes through the southern part of the community, along the edge of Bayou Boeuf, part of the Intracoastal Waterway. U.S. Route 90, a four-lane expressway, forms the northeastern border of the CDP but provides no direct access to it; the closest exits are Exit 176 in Morgan City to the west and Exit 181 in Amelia to the east.

According to the United States Census Bureau, the CDP has a total area of 0.85 square miles (2.2 km), of which 0.81 square miles (2.1 km) is land and 0.04 square miles (0.1 km), or 6.37%, is water.

Historical population

Census	Pop.	Note	%±
2010	422		—
2020	297		−29.6%
U.S. Decennial Census

Siracusaville first appeared as a census designated place in the 2010 U.S. Census.

Siracusaville CDP, Louisiana – Racial and ethnic composition
Note: the US Census treats Hispanic/Latino as an ethnic category. This table excludes Latinos from the racial categories and assigns them to a separate category. Hispanics/Latinos may be of any race.

Race / Ethnicity (NH = Non-Hispanic)	Pop 2010	Pop 2020	% 2010	% 2020
White alone (NH)	13	13	3.08%	4.38%
Black or African American alone (NH)	395	264	93.60%	88.89%
Native American or Alaska Native alone (NH)	0	0	0.00%	0.00%
Asian alone (NH)	1	0	0.24%	0.00%
Pacific Islander alone (NH)	0	0	0.00%	0.00%
Other race alone (NH)	3	0	0.71%	0.00%
Mixed race or Multiracial (NH)	10	10	2.37%	3.37%
Hispanic or Latino (any race)	0	10	0.00%	3.37%
Total	422	297	100.00%	100.00%