South Carolina Highway 181 (SC 181) is a 6.430-mile-long (10.348 km) state highway in the U.S. state of South Carolina. The highway connects the Georgia state line with Starr.

SC 181 begins at the Georgia state line at a point southwest of Starr, within Anderson County, where the roadway crosses over the Savannah River and continues as Georgia State Route 181 (Smith-McGee Highway). It travels to the northeast and has a brief concurrency with SC 187. The highway continues to the northeast and enters Starr. There, it meets its northern terminus, an intersection with SC 412 (Rainey Road/Stones Throw Avenue). Here, the roadway continues as Smith-McGee Road.

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The entire route is in Anderson County.

Location	mi	km	Destinations	Notes
​	0.000	0.000	SR 181 west (Smith–McGee Highway) – Hartwell	Continuation beyond Georgia state line over the Savannah River
​	2.370	3.814	SC 187 south – Elberton	Southern end of SC 187 concurrency
​	3.190	5.134	SC 187 north	Northern end of SC 187 concurrency
Starr	6.430	10.348	SC 412 (Rainey Road / Stones Throw Avenue) to SC 81 / Smith–McGee Road – Starr, Anderson	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• U.S. roads portal
• United States portal

• Media related to South Carolina Highway 181 at Wikimedia Commons
• SC 181 at Virginia Highways' South Carolina Highways Annex