South Carolina Highway 212 (SC 212) is a 5.670-mile (9.125 km) primary state highway in the U.S. state of South Carolina. It serves the town of Williams by connecting it with nearby highways.

SC 212 is a two-lane rural highway that connects the town of Williams between SC 64 and U.S. Route 21 (US 21). Within Williams, it intersects SC 362 at its eastern terminus.

Established around 1938 as a new primary routing as a spur from US 21 to Williams. In 1940, it was extended south to its current southern terminus at SC 64. In 1950, the entire route was completely paved.

The entire route is in Colleton County.

Location	mi	km	Destinations	Notes
​	0.000	0.000	SC 64 (Lodge Highway) – Lodge, Walterboro	Southern terminus
​	0.150	0.241	Sykes Road east (SC 212 Conn. east)	Western terminus of SC 212 Conn.
Williams	3.810	6.132	SC 362 west (Lumber Road)	Eastern terminus of SC 362
​	5.670	9.125	US 21 (Low Country Highway) – Yemassee, Branchville	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

South Carolina Highway 212 Connector
Location	Bells Crossroads, South Carolina
Length	0.130 mi (209 m)

South Carolina Highway 212 Connector (SC 212 Conn.) is a connector route that exists just northwest of Bells Crossroads. It connects SC 64 (Bells Highway) with the SC 212 mainline (Williams Road) just north of SC 212's southern terminus.

• U.S. roads portal

• Media related to South Carolina Highway 212 at Wikimedia Commons
• Mapmikey's South Carolina Highways Page: SC 212