South Carolina Highway 88 (SC 88) is a 14.350-mile (23.094 km) state highway in northern Anderson County, South Carolina with a brief entry into southern Pickens County, connecting Pendleton and areas south of Powdersville. It is sometimes considered an alternate route for U.S. Route 123 (US 123).

The route travels generally in a west–east direction, signed to begin at an intersection with SC 28 Business (SC 28 Bus.; North Mechanic Street) in downtown Pendleton. However, SCDOT designates the western terminus to not start until North Broad Street a few blocks later. East of Pendleton, SC 88 travels through somewhat rural areas and has a roundabout intersection with US 178. The route continues until it terminates at an intersection with SC 8, west of the suburban areas of Powdersville.

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County	Location	mi	km	Destinations	Notes
Anderson	Pendleton	−0.150	−0.241	SC 28 Bus. (North Mechanic Street) / West Queen Street – Anderson, Clemson, Tri-County Technical College, Woodburn Historical Home, Riverside Middle School	Signed western terminus
		0.000	0.000	North Broad Street / East Queen Street west – Tri-County Technical College	Official western terminus; East Queen Street continues past intersection.
Pickens	No major junctions
Anderson	​	7.870	12.666	US 178 (Liberty Highway) – Anderson, Liberty
	​	14.350	23.094	SC 8 (Pelzer Highway) – Pelzer, Easley, Greenville
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• U.S. roads portal

• Media related to South Carolina Highway 88 at Wikimedia Commons