South Portsmouth–South Shore station is an Amtrak intercity rail station in South Shore, Kentucky. It primarily serves the city of Portsmouth, Ohio, located across the Ohio River.

In pre-Amtrak years several C&O trains served a different station in Portsmouth: Fast Flying Virginian (west to Cincinnati, and sections east to Washington, D.C., and Newport News), George Washington (sections west to Cincinnati and Louisville, and sections east to Washington, D.C. and Newport News) and the Sportsman (northwest to Detroit, and sections east to Washington, D.C., and Newport News). Norfolk & Western trains called at another station in Portsmouth: Pocahantas (Cincinnati and Columbus – Norfolk) and Powhatan Arrow (Cincinnati – Norfolk).

The station was opened as a flag stop for the James Whitcomb Riley and Mountaineer on June 15, 1976. Service to the stop was suspended on April 29, 1979, but resumed on April 27, 1980. In January 2011, the station was made accessible (with a wheelchair lift) using American Recovery and Reinvestment Act funding. The original shelter, built when the station opened in 1976, was replaced by a brick structure in early 2023. In addition to the new station building, improvements include new lighting and fencing as well as a new concrete platform with tactile edging.

Media related to South Portsmouth–South Shore station at Wikimedia Commons

• South Shore, KY – Amtrak
• South Shore, KY – Station history at Great American Stations (Amtrak)