St. Anne-Pacelli Catholic School is named for Saint Anne, the mother of the Virgin Mary, and Pope Pius XII (Eugenio Pacelli). The school's history stretches back to 1868. Located in Columbus, Georgia, St. Anne-Pacelli is the only Preschool (age 1)-12th grade Catholic school serving southwestern Georgia.

In 1868, the Sisters of Mercy purchased a home in Downtown Columbus, Georgia and converted it into a convent. St. Joseph's Academy, a K–8 school, was formed at the same location in 1868. The school remained in Downtown Columbus until 1952, when population growth led to the establishment of a new Catholic school near Midtown Columbus. St. Joseph's then merged with this school.

Until St. Anne Church was built in 1961, the school operated under the name Holy Family School, and was operated by the Church of the Holy Family. The name was then changed to St. Anne School. In 2008, it was joined with Pacelli High School.

St. Anne-Pacelli Catholic School's athletic program begins in elementary school, as young as third grade. Middle and high school athletes compete in 14 sports.

At the varsity level, St. Anne-Pacelli competes as a Single A member of the Georgia High School Association (GHSA).

The following sports programs are available for students: Baseball: grades 6-12; Boys' Basketball: grades 1-12; Boys' Cross Country: grades 5-12; Boys' Football: grades 6-12; Boys' Golf: grades 5-12; Boys' Soccer: grades 6-12; Boys' Swimming: grades 6-12; Boys' Tennis: grades 3-12; Boys' Track and Field: grades 8-12; Boys' and Bigger Dudes' Wrestling: grades 6-12.

• School website

• Pacelli High School (Columbus, Georgia)