The high school began classes on August 31, 2009, with an enrollment of 107 students. It was the first new Catholic high school in the Milwaukee archdiocese in more than 25 years and the first Catholic high school on the south side within the boundaries of the city of Milwaukee since St. Mary's Academy closed in 1991. Previous leadership includes Father Cliff Ermatinger (Pastor) and Zeus Rodriguez (President 2012 - 2016) "reference". Retrieved 2024-08-12.
Curriculum
St. Anthony School is an official international baccalaureate candidate school, and is expected to be certified for the 2015-16 school year.
Athletics
In 2012, the boys soccer team won the Division III state championship in the second year of the program's existence.