St. Francis Catholic High School is a four-year, all-female college preparatory high school in Sacramento, California, United States. It is one of four Catholic high schools in Sacramento affiliated with the Roman Catholic Diocese of Sacramento, and draws students from over fifty private and public feeder schools in the California counties of Sacramento, Yolo, El Dorado and Placer. The school was established in 1940.

During the 2003–2004 school year, St. Francis completed the first phase of its campus renovation and expansion that doubled the size of its facilities. These new buildings include The Fine and Performing Arts Complex, Library/Resource Center, Gymnasium/Fitness Complex, four science labs, the Administration Building, and the Carlsen and Demetre Center for Campus Life (CLC).

St. Francis started in the fall of 1940 with 12 female students from nearby St Francis Elementary. The school was run by the St. Francis Sisters of Penance and Christian Charity.

In 1975 the Sisters of Notre Dame and the Franciscan Sisters were no longer able to staff the school, and Bishop Alden J. Bell appointed the Sisters of the Apostles of the Sacred Heart of Jesus, who served until 1999.

This article's list of alumni may not follow Wikipedia's verifiability policy. Please improve this article by removing names that do not have independent reliable sources showing they merit inclusion in this article AND are alumni, or by incorporating the relevant publications into the body of the article through appropriate citations. (March 2019)

• Meghan Hays, communications executive
• Lio Tipton, credited as Analeigh Tipton through to 2021, actress and a contestant on America's Next Top Model, Cycle 11
• Greta Gerwig (2002), actress and filmmaker
• Eleni Kounalakis (1985), Lieutenant Governor of California

• Official website