Saint Joseph High School (commonly referred to as St. Joe) is a Roman Catholic college preparatory high school located in South Bend, Indiana. Formerly located adjacent to the campuses of the University of Notre Dame, St. Mary's College, and Holy Cross College, in 2012, the school moved to a new location about a mile south of Notre Dame. It is located within the Diocese of Fort Wayne–South Bend.

Saint Joseph's High School began classes on September 20, 1953, as the first consolidated, co-institutional Catholic high school in the South Bend area. The school was made up of students from Central Catholic High School, Saint Hedwig School, Saint Joseph's Academy, and South Bend Catholic High School.

Contributions from South Bend and Mishawaka parishioners enabled building the school on 5.7 acres (23,000 m) of land donated to the Diocese of Fort Wayne-South Bend by the Brothers of Holy Cross.

From 1953 to 1968, Saint Joseph's High School had separate divisions for boys and girls. The faculty consisted primarily of Sisters of the Holy Cross and Brothers of Holy Cross. In 1968 the school became coeducational.

In 2012, St. Joseph's constructed a new building on the site formerly occupied by Saint Joseph Regional Medical Center. Along with the new building, the official name of the school was changed from Saint Joseph's High School to Saint Joseph High School.

SJHS is accredited by the Indiana Department of Education and the North Central Association of Colleges and Schools and is also a member of the National Catholic Education Association.

17 different AP classes are offered. St Joe has been named a Blue Ribbon school by the United States Department of Education.

AP classes offered include AP Biology, AP Calculus AB, AP Calculus BC, AP Chemistry, AP Computer Science A, AP English Language and Composition, AP Environmental Science, AP Latin, AP Macroeconomics, AP Microeconomics, AP Physics C, AP Spanish, AP Statistics, AP United States Government and Politics, AP United States History.

SJHS was named one of the Top 50 Catholic High Schools in the Catholic High School Honor Roll every year from 2006 to 2013.

• Euro Challenge
• Fed Challenge
  • National Champions in 2010
• Quiz Bowl
  • Traditional State Champions in 2013, Rotary State Champions in 2013, 2014, 2015

The Saint Joseph Indians are a member of the Northern Indiana Conference. Fellow member Mishawaka Marian is Saint Joe's archrival; the SJHS Huskies, formerly Indians, and the Marian Knights battle annually for the Bishop's Trophy. Sports offered are:

• Tom Abernethy, National Basketball Association (NBA) basketball player
• Paul Appleby, singer
• Brendan Bayliss, singer/guitarist of the band Umphrey's McGee
• Pete Buttigieg, United States Secretary of Transportation, former mayor of South Bend, Indiana, 2020 presidential candidate
• Nathan Gunn, Award-winning baritone opera singer
• Traci Paige Johnson, animator and television producer, creator of Blue's Clues
• Joe Kernan, former governor of Indiana, former mayor of South Bend, Indiana
• James Mueller, mayor of South Bend, Indiana
• John Laskowski, Indiana University basketball broadcaster, former NBA Player and member of IU's national championship team
• Mike McNeill, former NHL hockey player
• Steve Ontiveros, former MLB pitcher; 1994 All Star with Oakland Athletics; American League ERA Leader 1994
• Clarissa Pinkola Estés, poet, post-trauma specialist, and Jungian psychoanalyst
• Mike Schmuhl, political campaign manager
• Jake Teshka, politician

• List of high schools in Indiana

• Official website