Sandusky Central Catholic School is a Catholic, private school in Sandusky, Ohio. Founded in 1902, it is administered by the Roman Catholic Diocese of Toledo.

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Three area Catholic schools combined in 2003: Holy Angels, Sts. Peter and Paul, and St. Mary. The school's superintendent became Sr. Mary Jon Wagner. Originally the school's new name was to be Trinity Catholic School. Since then the entire school system has become Sandusky Central Catholic Schools, and the high school campus has remained St. Mary Central Catholic.

• Boys basketball – 1936, 1980
• Boys wrestling – 1994, 2000, 2002, 2003, 2004, 2005, 2006
• Girls cross country – 1987, 1988, 1989, 1990
• Boys swimming – 2010

• Bob Brotzki, former NFL player

• On February 1, 2013, St. Mary announced they would be forming a new league called the Sandusky River League in 2014–15 with Tiffin Calvert, Lakota, New Riegel, Old Fort, and Fremont St. Joe's. This league ultimately gave a home to the remaining MAL schools. However, the SRL was absorbed by the Sandusky Bay Conference in 2016–17, bringing the Panthers back into their traditional league home where they compete in the River Division.

• School Website