St. Nicholas Cathedral (Russian: Свято-Николаевский собор) is a Russian Orthodox church in Dushanbe, Tajikistan. It is the Cathedral church of the Russian Orthodox Eparchy of Dushanbe and Tajikistan.

The cathedral was completed at the end of 1943 due to a certain softening that occurred in the USSR in relation to the Patriarchal Church that year.

After the collapse of the USSR, a large number of Orthodox families left the country, leaving the cathedral with no visitors. In the spring of 2005, the St. Nicholas Cathedral began its first major reconstruction, which continued until 2011.

• Russians in Tajikistan
• Christianity in Tajikistan
• Dushanbe

38°33′59.3″N 68°49′0.3″E / 38.566472°N 68.816750°E / 38.566472; 68.816750