St Agnes' Lifeboat Station was situated in St Agnes, Isles of Scilly and provided a service for the Royal National Lifeboat Institution from 1890 to 1920. The lifeboat station and slipway still exist, and have been identified by the Isles of Scilly Council as a Building of Local Significance.

The station opened in 1891 with a single slipway. A new slipway was provided in 1904 at a cost of £5,000 (equivalent to £680,000 in 2023) to the designs of the Institution's Architect, W.T. Douglass. From the back of the boat house to the toe of the slip it was 1,068 feet (326 m). It was built of Jarrah wood from Western Australia, bolted to granite and concrete pillars, with the exception of a short piece at the upper end, built on the rocks. Two rails ran the entire length of the slip, on which rested the double bogey trolley that carried the boat. Rails were also laid down the old slip which could be used at high tide.

The station was closed in 1920.

On 13 December 1907, the Thomas W Lawson of Boston, US, was in distress off Annet. The St Agnes Lifeboat put William Thomas Hicks on board to act as pilot. But the schooner foundered at Minmanueth and he was lost together with fifteen of the vessel's crew. His son, Frederick Charles Hicks, put off with seven other men in the gig 'Slippen' which rescued the schooner's captain and engineer form Hellweather rock.

Frederick Charles Hicks was awarded the RNLI Silver Medal for bravery, when swimming from a gig to save the captain of the Thomas W Lawson. The United States government gave him a gold watch, and gold medals to all the crewe of the gig 'Slippen'.

At St Agnes	ON	Name	Class	Notes
1890–1904	275	James and Caroline	Self-righting	31 ft 1 in (9.47 m) lifeboat. Later saw service at Upgang and Criccieth.
1904–1909	516	Charles Deere James	Liverpool	Built by the Thames Ironworks and Shipbuilding Company. 38 ft (12 m) long and 10 ft (3.0 m) broad with 10 oars, was fitted with two drop keels and two water ballast tanks.
1909–1920	590	Charles Deere James	Watson	Built by the Thames Ironworks and Shipbuilding Company. 38 ft (12 m) long and 9.33 ft (2.84 m) broad with 10 oars and fitted with a drop keel.