St Luke's Church of England School is a co-educational secondary school located in Exeter in the English county of Devon. It is a Church of England school under the jurisdiction of the Diocese of Exeter.

It was originally known as St Luke's Church of England High School, but when the school gained specialisms in science and sports it was renamed St Luke's Science and Sports College. In February 2020 St Luke's Science and Sports College converted from being a voluntary controlled school administered by Devon County Council to being an academy sponsored by The Ted Wragg Multi Academy Trust. It was then renamed St Luke's Church of England School.

St Luke's Church of England School offers GCSEs and BTECs as programmes of study for pupils.

• St Luke's Church of England School official website