State Route 104 (SR 104) is a 114.43-mile-long east–west state highway in West Tennessee.

SR 104 begins as a secondary highway in Dyer County on the banks of the Mississippi River. It goes east to have an intersection with SR 181 (Great River Road) before crossing over the Obion River to pass through Finley, where it has an intersection with SR 182. The highway now enters Dyersburg and passes through industrial areas before having an intersection with US 51/SR 3 (Highway 51 Bypass). SR 104 then passes through neighborhoods before entering downtown along Forrest Street to have an intersection with SR 78 (Lake Road), where it becomes McGaughey Street. It then becomes concurrent with US 51 Bus./SR 211 (Troy Avenue) for a short distance as it turns south along N Main Avenue before splitting off and going east along E Court Street. The highway passes through more neighborhoods before coming to an interchange with US 412/SR 20, where SR 104 leaves Dyersburg and becomes a primary highway. SR 104 passes through RoEllen before crossing into Gibson County via a bridge over the North Fork of the Forked Deer River. The entire route of SR 104 in Dyer County is a two-lane highway.

SR 104 then passes through Eaton, where it has an intersection with SR 188, before widening to a 4-lane divided highway as it continues east through farmland to come to an intersection with SR 457, where it narrows to 2-lanes and enters Trenton. It passes through downtown along Eaton Street, where it has an intersection with SR 367, before coming to an intersection with US 45W/SR 43/SR 54/SR 77. SR 104 now becomes concurrent with SR 77, where SR 104 becomes unsigned, and they leave Trenton and cross another bridge over the North Fork of the Forked Deer River. SR 77/SR 104 pass by Gibson County Airport before entering Milan as N Main Street. They pass through neighborhoods before making a left onto Front Street to come to an intersection and become concurrent with US 45E/SR 43 (S 1st Street), where SR 77 also becomes unsigned. They pass through downtown as a 4-lane undivided highway to come to an intersection with US 70A/US 79/SR 76 (Van Hook Street), where SR 77 splits off follows that highway. SR 104 splits off from US 45E/SR 43 a short distance later along Ellington Drive as a signed secondary highway. SR 104 goes east as a 2-lane highway to leave Milan and cross into Carroll County.

SR 104 passes through rural and slightly hilly terrain as it has a short concurrency with SR 220 before coming to an intersection with US 70/SR 1. It turns southeast, along US 70/SR 1, to pass through Cedar Grove, where it has another intersection with SR 220 before SR 104 splits off and goes southeast to cross into Henderson County.

SR 104 becomes very curvy as it passes through hilly terrain to have an interchange with I-40 (Exit 101). It then continues southeast through farmland to enter Lexington and pass along the western shore of Beech Lake to come to an intersection and become concurrent with US 412/SR 20 (W Church Street). They pass just south of the Beech River Dam and cross over the Beech River as a 4-lane undivided highway to pass through a business district before entering downtown to have an intersection with SR 22 (Broad Street) before SR 104 splits off at an intersection with SR 114 (Natchez Trace Drive). The highway then makes a left onto S Main Street and heads southeast to have another crossing of the Beech River to leave Lexington as a 2-lane highway to pass through hilly and wooded areas. SR 104 then passes through Reagan, where it has an intersection with SR 100, before passing through the town of Sardis, where it has a concurrency with SR 201 and an intersection with SR 421. The highway continues southeast to cross into Hardin County and come to an end at an intersection with SR 69 at the western edge of Saltillo.

County	Location	mi	km	Destinations	Notes
Dyer	​	0.0	0.0	Dead end at the Mississippi River	Western terminus; SR 104 begins as a secondary highway
	​			SR 181 (Great River Road) to I-155 – Ridgely, Halls
	​			Bridge over the Obion River
	Finley			SR 182 north (Lenox Nauvoo Road) to I-155 – Lenox	Southern terminus of SR 182
	Dyersburg			US 51 (Highway 51 Bypass/SR 3) to I-155 – Halls, Union City
				SR 78 north (Lake Road) to I-155 – Ridgely	Southern terminus of SR 78
				US 51 Bus. north (Troy Avenue/SR 211 north)	Western end of US 51 Bus./SR 211 concurrency
				US 51 Bus. south (S Main Avenue/SR 211 south)	Eastern end of US 51 Bus./SR 211 concurrency
				US 412 (SR 20) – Jackson, Union City	Interchange; SR 104 turns primary
North Fork of the Forked Deer River				Bridge over the North Fork of the Forked Deer River
Gibson	Eaton			SR 188 (Riverside Yorkville Road) – Yorkville, Maury City
	​			SR 457 east – Humboldt	Western terminus of SR 457; bypass of Trenton
	Trenton			SR 367 (College Street)
				US 45W / SR 54 / SR 77 west (Highway 45 Bypass/SR 5) – Dyer, Bradford, Alamo, Humboldt	Western end of SR 77 concurrency; SR 104 becomes unsigned
				Bridge over the North Fork of the Forked Deer River
	Milan			US 45E north (S 1st Street/SR 43 north) – Bradford	Western end of US 45E/SR 43 concurrency
				US 70A / US 79 (Van Hook Street/SR 76/SR 77 east) – Gibson, Atwood	Eastern end of SR 77 concurrency
				US 45E south (S 1st Street/SR 43 south) – Medina	Eastern end of US 45E/SR 43 concurrency; SR 104 becomes signed as secondary highway
Carroll	​			SR 220 south – Lavinia	Western end of SR 220 concurrency
	​			SR 220 north – Atwood	Eastern end of SR 220 concurrency
	​			US 70 east (SR 1 east) – Huntingdon	Western end of wrong-way US 70/SR 1 concurrency
	Cedar Grove			SR 220 north – Lavinia	Southern terminus of SR 220
				US 70 west (SR 1 west) – Jackson	Eastern end of wrong-way US 70/SR 1 concurrency
Henderson	​			I-40 – Memphis, Jackson	I-40 exit 101
	Lexington			US 412 west (W Church Street/SR 20 west) – Jackson	Western end of US 412/SR 20 concurrency
				Bridge over the Beech River
				SR 22 (Broad Street) – Milledgeville, Parkers Crossroads
				US 412 east / SR 114 south (E Church Street/SR 20 east) – Chesterfield, Parsons SR 114 north (Natchez Trace Drive) – Natchez Trace State Park	Eastern end of US 412/SR 20 concurrency
				Bridge over the Beech River
	Reagan			SR 100 – Henderson, Scotts Hill
	Sardis			SR 201 north (Sardis Scotts Hill Road) – Scotts Hill	Western end of SR 201 concurrency
				SR 201 south (Henderson Road)	Eastern end of SR 201 concurrency
				SR 421 south (Hinkle Road) – Lebanon	Northern terminus of SR 421
Hardin	Saltillo	114.43	184.16	SR 69 – Milledgeville, Bath Springs	Eastern terminus; SR 104 ends as a secondary highway
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• List of state routes in Tennessee
• List of highways numbered 104

Media related to Tennessee State Route 104 at Wikimedia Commons