State Route 22 (SR 22) is a 168.5-mile (271.2 km) state highway that extends from Safford in Dallas County to the Georgia state line near Roanoke in Randolph County. The route travels across most of the state from west to east.

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Starting at an intersection with SR 5 in Safford, the route travels northeast through Selma and Maplesville. At Clanton the highway is concurrent for 8 miles (13 km) with U.S. Route 31 (US 31), including an intersection with Interstate 65 (I-65) near the geographical center of the state. The route proceeds towards Verbena and then crosses Lake Jordan.

The route continues east-northeast through Rockford, Alexander City, New Site and Roanoke on its way to the Georgia state line, where the road becomes Georgia State Route 34. The route is paved throughout and occasionally multi-lane. Counties traversed by the route include Dallas, Chilton, Coosa, Tallapoosa, Chambers, and Randolph.

County	Location	mi	km	Destinations	Notes
Dallas	Safford	0.000	0.000	SR 5 – Mobile, Browns, Birmingham	Western terminus
	​	19.181	30.869	SR 219 north / SR 22 Truck east	Southern terminus of SR 219; western terminus of SR 22 Truck
	Selma	23.487	37.799	US 80 Bus. east (Broad Street/SR 8) – Montgomery	Western end of US 80 Bus./SR 8 concurrency
		24.989	40.216	US 80 / SR 14 / SR 22 Truck west (Highland Avenue/SR 8) – Meridian, Prattville	Eastern end of US 80 Bus./SR 8 concurrency; eastern terminus of SR 22 Truck
Chilton	Maplesville	50.214	80.812	US 82 (SR 6) – Centreville, Prattville, Tuscaloosa	Interchange
		51.702	83.206	SR 22 Truck east (Foshee Avenue)	Western terminus of SR 22 Truck
		51.765	83.308	SR 139 north – Randolph, Birmingham	Northern terminus of SR 139
		51.935	83.581	SR 22 Truck west (Foshee Avenue) – truck route to SR 139	Eastern terminus of SR 22 Truck
	​	54.672	87.986	SR 191 north – Jemison, Birmingham	Southern terminus of SR 191
	Clanton	66.717	107.371	US 31 north (7th Street/SR 3) / SR 145 north (4th Avenue North) – Birmingham	Western end of US 31/SR 3 concurrency
		70.962	114.202	I-65 – Birmingham, Montgomery	I-65 exit 205
	​	75.019	120.731	US 31 south (SR 3) – Verbena	Eastern end of US 31/SR 3 concurrency
Coosa	Rockford	95.972	154.452	US 231 / SR 21 (Main Street/SR 53) – Sylacauga, Wetumpka
	​	104.049	167.451	SR 9 south – Wetumpka	Western end of SR 9 concurrency
	​	104.092	167.520	SR 9 north – Goodwater	Eastern end of SR 9 concurrency
Tallapoosa	Alexander City	110.890	178.460	SR 259 south	Northern terminus of SR 259
		112.864	181.637	US 280 west (SR 38) / Lee Street – Alexander City, Sylacauga, Birmingham	Western end of US 280/SR 38 concurrency
		114.556	184.360	US 280 east (SR 38) / SR 63 south – Dadeville, Eclectic	Eastern end of US 280/SR 38 concurrency; western end of SR 63 concurrency
		116.307	187.178	SR 63 north (Central Avenue)	Eastern end of SR 63 concurrency
	New Site	129.507	208.421	SR 49 south – Horseshoe Bend National Military Park	Western end of SR 49 concurrency
		130.526	210.061	SR 49 north – Ashland, Lineville	Eastern end of SR 49 concurrency
Chambers	No major junctions
Randolph	Wadley	146.492	235.756	SR 77 north – Ashland, Southern Union State Community College	Western end of SR 77 concurrency
	​	147.803	237.866	SR 77 south – LaFayette, Abanda	Eastern end of SR 77 concurrency
	Roanoke	160.107	257.667	US 431 (SR 1) – Wedowee, LaFayette
	​	168.543	271.244	SR 34 east – Franklin	Georgia state line; eastern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

State Route 22 Truck
Location	Selma
Length	3.4 mi (5.5 km)

The entire route is in Dallas County.

Location	mi	km	Destinations	Notes
​	0.00	0.00	SR 22 / SR 219 begins	Western terminus; southern terminus of SR 219; western end of SR 219 concurrency
Selma	1.2	1.9	US 80 west / SR 219 north – Meridian	Eastern end of SR 219 concurrency; western end of US 80 concurrency
	2.1	3.4	SR 14 west	Western end of SR 14 concurrency
	2.7	4.3	US 80 east / US 80 Bus. east / US 80 Truck east / SR 14 east / SR 22	Eastern terminus; eastern terminus of US 80 Business; eastern end of SR 14 concurrency
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

State Route 22 Truck
Location	Maplesville
Length	0.3 mi (480 m)

The entire route is in Chilton County.

Location	mi	km	Destinations	Notes
Maplesville	0.00	0.00	SR 22	Southern terminus
	0.3	0.48	SR 22	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• United States portal
• U.S. roads portal

• Rand McNally: The Road Atlas 2002, Rand McNally and Company 2001 ISBN 0-528-84446-6

• Southeastroads.com web page on SR-22 with photos