State Route 59 (SR 59) is a 94-mile (151 km) state highway in Baldwin and Monroe counties in the southwestern portion of the U.S. state of Alabama. The highway extends from Gulf Shores on the Gulf of Mexico coast to Uriah in rural southwestern Alabama.

The route begins at a junction with SR 21 in Uriah. The route maintains an east-to-west route for about ten miles until it reaches Georgetown. Here it turns north-to-south. The route continues south until it crosses into Baldwin County.

It reaches Bay Minette and junctions with SR 225, and eventually I-65 at mile 34. The route then continues south to SR 287, also known as the Gulf Shores Parkway. That route is an effective route for people heading to Montgomery and beyond from Gulf Shores. The routes swap right-of-ways and SR 59 continues along the Gulf Shores Parkway. The route reaches US 31 soon. The two routes engage in a concurrency to Stapleton. US 31 splits off from SR 59 and heads towards Mobile. SR 59 continues downwards to Loxley, where it junctions with I-10 at a Parclo Interchange at exit 44.

It then engages with a much shorter concurrency with US 90 (much shorter than its concurrency with US 31). The route continues south to Foley, which is home to its notable junction with the Foley Beach Express access road and its other notable junction with US 98.

After passing by The Park at OWA and a Lambert's Cafe, the route makes a short journey south to the Pelican Place at Craft Farms. Just past that point, the route makes a slight curve and The Track Family Fun Center comes into play, a small entertainment complex. Immediately after that junction, the road crosses Portage Creek into Gulf Shores. Here, Waterville USA, the famous Blalock Seafood store, and Lulu's Seafood, plus multiple high-rise condominiums come into view. The route junctions with SR 180 and hits the last stretch of regular stores in the area before reaching SR 182, also known as the famous Alabama's Coastal Connection, which is its southern terminus.

County	Location	mi	km	Destinations	Notes
Baldwin	Gulf Shores	0.000	0.000	SR 182	Southern terminus
		1.110	1.786	SR 180 to Foley Beach Express north – toll ferry, State Park Cabins, Fort Morgan, Wildlife Refuge
	Foley	10.921	17.576	US 98 (Laurel Avenue / SR 42) to Foley Beach Express south
	​	13.995	22.523	Foley Beach Express south – Gulf Shores, Orange Beach, Beaches, Elberta, Lillian
	Robertsdale	20.968	33.745	SR 104 west / CR 83 east – Silverhill	Eastern terminus of SR 104
		22.457	36.141	US 90 east (SR 16) – Pensacola	South end of US 90/SR 16 concurrency
	Loxley	27.830	44.788	US 90 west (SR 16) – Mobile	North end of US 90/SR 16 concurrency
		29.349	47.233	I-10 – Mobile, Pensacola	I-10 exit 44
	Stapleton	35.241	56.715	US 31 south (SR 3) – Mobile, Spanish Fort	South end of US 31/SR 3 concurrency
	Bay Minette	45.868	73.817	US 31 north (D'Olive Street / SR 3)	North end of US 31/SR 3 concurrency
		48.412	77.912	SR 287 to I-65 – Montgomery, Bay Minette
	​	52.209	84.022	I-65 – Mobile, Montgomery	I-65 exit 34
	Stockton	55.759	89.735	SR 225 south	Northern terminus of SR 225
Monroe	Uriah	93.670	150.747	SR 21 – Frisco City, Atmore, Pensacola	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• U.S. roads portal
• United States portal

• Rand McNally: The Road Atlas 2002, Rand McNally and Company 2001 ISBN 0-528-84446-6

• Southeastroads.com web page on SR-59 with photos
• Alabama Department of Transportation county road maps for Baldwin and Monroe (Adobe Acrobat reader required for maps; enlargement of maps necessary for legibility)