Stella Pepper Gyles House is a historic home located near Georgetown, Sussex County, Delaware. It is dated to the mid-19th century, and is a large two-story, five-bay, single-pile frame and shingle farmhouse with a three-bay side wing. It has a small lean-to rear wing attached to the rear of the three-bay wing. At the front entrance is a one-story, one-bay pedimented porch. The house is constructed of cypress and is in a vernacular Greek Revival style. Located on the property are a notable milk house, a mid-19th century barn, and a granary.

It was added to the National Register of Historic Places in 1979.