Interstate 35E (I-35E), a north–south Interstate Highway, is the eastern half of I-35, where it splits to serve the Dallas–Fort Worth metropolitan area. I-35 splits into two branch routes, I-35W and I-35E, at Hillsboro. I-35E travels north for 97 miles (156 km), maintaining I-35's sequence of exit numbers. It travels through Dallas before rejoining with I-35W to reform I-35 in Denton.

During the early years of the Interstate Highway System, branching Interstates with directional suffixes, such as N, S, E, and W, were common nationwide. On every other Interstate nationwide, these directional suffixes have been phased out by redesignating the suffixed route numbers with a loop or spur route number designation (such as I-270 in Maryland, which was once I-70S) or, in some cases, were assigned a different route number (such as I-76, which was once I-80S). In the case of I-35 in the Dallas–Fort Worth area, since neither branch is clearly the main route and both branches return to a unified Interstate beyond the cities of Dallas and Fort Worth, the American Association of State Highway and Transportation Officials has allowed the suffixes of E and W in Texas to remain in the present day. I-35 also splits into I-35E and I-35W in Minneapolis–St. Paul, Minnesota, for similar reasons as the I-35 split in the Dallas–Fort Worth area.

I-35E travels concurrently with US 67 from just north of Kiest Boulevard in the Oak Cliff area of Dallas to the I-30 interchange in Downtown Dallas. From there, US 67 joins with I-30. On both segments, US 67 is unsigned.

From Waco, Texas, to El Dorado, Kansas, I-35 (or I-35E) typically runs concurrent with or lies fairly close to US 77. This highway travels parallel to I-35E after splitting off of I-35 north of Hillsboro, running through Italy and Milford. It joins with I-35E for less than one mile (1.6 km) just south of Waxahachie before splitting back off to run through Waxahachie. It rejoins the Interstate just north of a junction with State Highway 342 (SH 342) in Red Oak. US 77 stays with the Interstate through Dallas and up to the southeastern section of Denton. It then breaks off, rejoining I-35 north of the city. Except for the spur sections (Denton and the section between Red Oak and Hillsboro) and the portion from I-635 to the split in Denton, US 77 is unsigned.

From the Dallas–Ellis county line to Downtown Dallas, I-35E is called South R.L. Thornton Freeway and varies from 8 to 10 lanes plus HOV. The section from I-20 to Downtown Dallas underwent a major reconstruction by 2015 to 12 lanes. Reconstruction of I-35E and the downtown Mixmaster interchange with I-30 is planned as part of the Horseshoe Project, derived from the larger Pegasus Project. From this point, I-35E is named the Stemmons Freeway to Lewisville. This section will undergo reconstruction in three phases. The first, a widening of I-35E from I-635 to Denton, will start in late 2011 to over 16 lanes. The second, the LBJ Project, included elevated toll I-35E lanes by 2016. Last is the major reconstruction of the Stemmons Freeway from Downtown Dallas to I-635 to over 20 lanes by 2020.

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I-35E replaced most of US 77 between Hillsboro and Denton. US 77 is unsigned along the route, with the exception of the highway that runs through Waxahachie–Red Oak and Denton. I-35E was completed in the early 1960s.

When first designated, I-35W and I-35E were the only suffixed highways in Texas. Subsequently, I-69W, I-69E, and I-69C have been designated.

exit numbers and mileposts increase numerically from the south end, continuing the numbers used on I-35.

County	Location	mi	km	Exit	Destinations	Notes
Hill	​	371.1	597.2		I-35 south – Waco	I-35E south and I-35W merge into I-35
	​	371.3	597.5	370A	US 77 north / Spur 579 – Hillsboro	Southbound exit only
	​	371.8	598.4	370B	I-35W north – Ft Worth	Southbound exit only
	Carl's Corner	373.6	601.3	374	FM 2959 – Carl's Corner
	​	376.9	606.6	377	FM 934
Ellis	Milford	380.7	612.7	381	FM 566 (Milford Road)
		384.7	619.1	384	Derrs Chapel Road
	Italy	386.2	621.5	386	SH 34 – Italy, Ennis
	Forreston	390.8	628.9	391	FM 329 (Forreston Road)
	Waxahachie	397.7	640.0	397	US 77 – Waxahachie
		398.6	641.5	399	FM 66 to FM 876 / FM 1446	Signed as exits 399A (FM 66/FM 876) and 399B (FM 1446) southbound
		400.4	644.4	401A	Brookside Road
		401.8	646.6	401B	Bus. US 287 to FM 664 – Waxahachie
		402.6	647.9	403	US 287 – Corsicana, Ft Worth	Access to Baylor Scott & White Medical Center-Waxahachie
		404.3	650.7	404	FM 387 (Lofland Road)
		405.4	652.4	405	Lofland Road
		406.5	654.2	406	Sterrett Road
	Red Oak	408.0	656.6	408	To SH 342 – Red Oak (NB) US 77 (SB)	South end of the overlap with US 77
		409.6	659.2	410A	Red Oak Road
		410.6	660.8	410B	FM 664 (Ovilla Road)
Dallas	Lancaster–Glenn Heights line	412.0	663.0	412	Bear Creek Road
	Lancaster–DeSoto line	413.7	665.8	413	Parkerville Road
		414.2	666.6	414	FM 1382 (Belt Line Road)
		415.2	668.2	415	Pleasant Run Road
		416.1	669.6	416	Wintergreen Road
	Lancaster–DeSoto– Dallas tripoint	417.1	671.3	417	Danieldale Road, Wheatland Road
	Dallas	418.2	673.0	418	I-20 – Ft Worth, Shreveport	Signed as exits 418A (WEST) and 418B (EAST); Exits 467A-B (I-20)
		419.8	675.6	419	Camp Wisdom Road
		420.5	676.7	420	Laureland Road
		421.2	677.9	421	Loop 12 / Ann Arbor Avenue	Signed as exits 421A (EAST) and 421B (WEST)
		422.5	679.9	422A	Beckley Avenue / Overton Road	No direct southbound exit (signed at Kiest Boulevard)
		422.8	680.4	422B	Kiest Boulevard
		423.5	681.6	423A	US 67 south – Cleburne	South end of the overlap with US 67; southbound exit and northbound entrance
				♦	US 67 south	Access for reversible HOV lane only; southbound exit and northbound right entrance
		423.6	681.7	423B	Saner Avenue	No direct southbound entrance (signed via Kiest Boulevard)
		424.0	682.4	424	Illinois Avenue	Access to Illinois Station
		425.2	684.3	425A	Zang Boulevard / Beckley Avenue	Beckley Avenue not signed southbound
		425.7	685.1	425B	Beckley Avenue / 12th Street	Southbound exit and northbound entrance
		425.8	685.3	425C	Marsalis Avenue
		426.3	686.1	426A	Ewing Avenue	No direct northbound exit (signed at exit 425C)
		426.6	686.5	426B	8th Street
		426.7	686.7	426C	Jefferson Boulevard	Southbound exit and northbound entrance
		427.3	687.7	426C (NB) 427A (SB)	Colorado Boulevard	Access to Methodist Medical Center of Dallas
		427.6	688.2	427C (NB) 428B (SB)	Riverfront Boulevard, Cadiz Street
		427.7	688.3	428A (SB) 427A (NB)	I-30 east / Griffin Street – Texarkana, Downtown	North end of the overlap with US 67; Exits 45A-46A (I-30)
		427.9	688.6	428C	Reunion Boulevard, Commerce Street;	Signed as exit 428 northbound; Commerce Street is US 80 bus/former US 80
		428.0	688.8	428B (SB) 427B (NB)	I-30 west – Ft Worth	Exits 45A-46A (I-30)
		428.9	690.2	428 (NB) 429A (SB)	To I-45 / US 75 / Singleton Boulevard – Houston, McKinney	Access via Spur 366; no northbound access to Singleton Boulevard
		429.0	690.4	429B	Continental Avenue, Commerce Street WEST	Commerce Street WEST not signed northbound
		429.7	691.5	429C	Victory Avenue, Hi Line Drive	No direct southbound exit (signed at exit 430A)
		429.9	691.9	429D	Dallas North Tollway	Northbound exit and southbound entrance
		430.2	692.3	430A	Oak Lawn Avenue
		430.6	693.0	430B	Market Center Boulevard	Access to Market Center Station
		430.6	693.0	430C	Wycliff Avenue	No direct northbound exit (signed at exit 430B)
		431.3	694.1	431	Medical District Drive	Previously Motor Street
		431.9	695.1	432A	Inwood Road	Access to UT Southwestern Medical Center, Parkland Memorial Hospital, and Children's Medical Center
		432.8	696.5	432B	Commonwealth Drive
		433.4	697.5	433A	SH 183 to SH 114 – Irving, DFW Airport	Northbound exit and southbound entrance
		433.3	697.3	433B	Mockingbird Lane – Dallas Love Field Airport
		434.1	698.6	434A	Empire Central
		434.8	699.7	434B	Regal Row
		435.5	700.9	435	Harry Hines Boulevard	Northbound exit and southbound entrance, access to Bachman Station
		436.6	702.6	436A	Loop 12 / Spur 348 (Northwest Highway) – Irving, DFW Airport	Signed as exits 436A (SOUTH) and 436B (EAST) southbound
		436.8	703.0	436B	I-35E Express to I-635 Express east	Northbound exit and southbound entrance; south end of Express Lanes
		437.8	704.6	437	Mañana Road	Northbound exit only
		438.1	705.1	—	Loop 12 south	Southbound exit and northbound entrance for Express lanes only
		438.3	705.4	438	Walnut Hill Lane	Access to Walnut Hill/Denton Station
				—	Walnut Hill Lane	Southbound exit and northbound entrance for Express lanes only
		439.4	707.1	439	Royal Lane	Access to Royal Lane Station
		439.9	708.0	440A	Forest Lane	Northbound exit only
		440.1	708.3	440B	I-635 east / I-635 Express east	Includes free access from Express Lanes; Exits 27A-B-C (I-635)
				440C	I-635 west – DFW Airport	Exits 27B-C (I-635)
	Farmers Branch	440.8	709.4	441	Valley View Lane	Access to Farmers Branch Station
		441.8	711.0	442	Valwood Parkway
	Carrollton	442.9	712.8	443A	Crosby Road	No direct southbound exit (signed at exit 443B)
		443.1	713.1	443B	Belt Line Road	Access to Downtown Carrollton Station
		443.9	714.4	443C	Frontage Road	Former northbound exit only
		444.5	715.4	444	Whitlock Lane, Sandy Lake Road	Access to Trinity Mills Station
		445.4	716.8	445A	SH 190 / Dickerson Parkway	Southbound exit via exit 446
		445.5	717.0	445B	Pres. George Bush Turnpike
Denton		445.9	717.6	446	Frankford Road	Access to North Carrollton/Frankford Station
	Lewisville	447.4	720.0	447A	Sam Rayburn Tollway
		447.6	720.3	447B	SH 121
		448.2	721.3	448	FM 3040 (Round Grove Road) / Hebron Parkway	Access to Hebron Station
		449.6	723.6	449	Corporate Drive
		450.5	725.0	450	Bus. SH 121
		451.5	726.6	451	Fox Avenue
		451.9	727.3	452	FM 1171 (Main St)	Access to Medical City Lewisville
		452.7	728.6	453	Valley Ridge Boulevard
		453.5	729.8	454A	FM 407 (Justin Road) / Lake Park Road
	Lewisville–Highland Village line	454.9	732.1	454B	Garden Ridge Boulevard	Access to Highland Village/Lewisville Lake Station
	Hickory Creek	457.2	735.8	457	Lake Dallas Drive
	Lake Dallas	457.5	736.3	—	I-35E Express	Southbound exit and northbound entrance; north end of the Express Lanes
	Lake Dallas–Corinth line	457.7	736.6	458	FM 2181 / Swisher Road	Signed as exit 458A northbound; access to Lewisville Lake Toll Bridge
	Corinth	458.4	737.7	458B	Quail Run Drive	Northbound exit and southbound entrance
		459.2	739.0	459	Frontage Road
		460.3	740.8	460	Corinth Parkway
		461.4	742.6	461	Post Oak Drive, Lakeview Boulevard
	Denton	462.6	744.5	462	FM 2499 (State School Road) / Mayhill Road, Bucee's Boulevard/Brinker Road	Access to Denton Regional Medical Center and MedPark Station
		462.9	745.0	463	Loop 288 / Lillian Miller Parkway	Access to MedPark Station
		464.6	747.7	464	US 77 north (Dallas Drive) – Denton	North end of the overlap with US 77; northbound exit and southbound entrance
		464.9	748.2		Pennsylvania Drive	Former southbound exit only
		465.1	748.5	465A	FM 2181 (Teasley Lane)
		465.7	749.5	465B	US 377 (Fort Worth Drive)
		466.6	750.9	466A	McCormick Street
		467.0	751.6	466B	North Texas Boulevard
		467.4	752.2	467	I-35W south / FM 1515 west (Bonnie Brae Street) / Airport Road – Fort Worth	Northbound exit and southbound entrance; Exit 85A (I-35W), access to Texas Health Presbyterian Hospital Denton
		467.8	752.9		I-35 north – Oklahoma City	I-35E north and I-35W merge into I-35
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Closed/former       Concurrency terminus       Electronic toll collection       HOV only       Incomplete access       Route transition

• I-635, while technically a loop of I-35, only intersects I-35E and neither I-35 nor I-35W.

• Texas portal
• U.S. Roads portal

• Interstate Guide: I-35E & I-35W (Texas)
• I-35E south of downtown Dallas—from dfwfreeways.info
• I-35E north of downtown Dallas—from dfwfreeways.info