Tamarack Run Natural Area is a 234-acre (95 ha) protected area in Sullivan County, Pennsylvania, United States. It is part of Loyalsock State Forest.

The Natural Area protects a wetland featuring a population of tamarack trees which are relatively rare in Pennsylvania. The area also features two endangered plants: manna grass and Tuckerman's pondweed, and most of the area is a boggy marsh that makes visiting on foot difficult, though it is bordered by two gravel roads. The Natural Area can also be accessed via the long-distance Loyalsock Trail which passes near its northern boundary.