The Templo Expiatorio del Santísimo Sacramento is a Catholic church dedicated to the Blessed Sacrament, located in Guadalajara, Jalisco, Mexico. It is of neo-Gothic style and is considered the greatest work of its kind in Mexico. Its construction began on August 15, 1897 and ended 75 years later in 1972.

The idea of building a temple dedicated to the Blessed Sacrament in the city of Guadalajara began in the late 19th century, when a congregation of Catholics formed a committee to make this temple. So the archbishop of the city, Pedro Loza y Pardavé, together with the commission organized a competition among some architects and engineers to select the project of the temple.

The original project was designed by Eng. Salvador Collado Jasso (Arcediano Bridge), but after he died of yellow fever, the construction remained incomplete. Later, to continue the project, architect Adamo Boari was selected. Adamo Boari was a famous Italian architect brought by then-President of Mexico Porfirio Díaz, who had earlier worked in the projects of the Palacio de Bellas Artes and the Palacio de Correos de Mexico in Mexico City.

The construction began with a ceremony hosted by Archbishop Pedro Loza y Pardavé and Pedro Romero. The cornerstone was laid on August 15, 1897, and by 1911 the interior columns were already finished. The canon Pedro Moreno and foreman Feliciano Arías were in charge of the project, of whom the latter was succeeded by his son Jerónimo Arías after his death. Work on the temple was suspended during the Revolution due to religious persecution, lack of guarantees and an economic crisis that the country faced as a result of the conflict.

In February 1924, Pedro Romero died and it was assigned to the priest José Garibi Rivera the completion of the temple. He immediately asked engineer Luis Ugarte to assist him in the work. The construction boomed, and on January 6, 1927, the project was assigned to architect Ignacio Díaz Morales who oversaw the work until its completion in 1972.