In Tennessee, U.S. Route 64 (US 64) stretches 404.1 miles (650.3 km) from the Mississippi River (Arkansas state line) in Memphis to the North Carolina state line near Ducktown. The highway, along with US 72, is a major route for travel between Memphis and Chattanooga.

The route between Cleveland and the eastern end of the Ocoee Scenic Byway follows the route of the Old Copper Road, a wagon trail dating back to the 1830s used for transporting copper from the mines in the Copper Basin to Cleveland and Chattanooga.

The route originally continued westward from downtown Cleveland, crossing the Tennessee River at a ferry in Hamilton County, through Soddy-Daisy and across the Cumberland Plateau, and joined where the concurrency splits from US 41 (now part of Interstate 24) near Pelham. This designation was removed in 1940 after the Chickamauga Dam went into operation, flooding much of the original route, and the route was moved to its present concurrency with US 11 and 41. Much of this original route no longer exists even as county maintained road. The Tennessee Department of Transportation (TDOT) has plans to restore this route with a new four lane highway and toll bridge across the Tennessee River, providing Clevelanders with a more convenient access to Nashville.

The Ocoee Scenic Byway was the first National Forest Scenic Byway in the nation, designated on July 22, 1988 by the United States Forest Service (USFS). TDOT plans to remove the designation of US 64 from the Ocoee Scenic Byway, and build a new four lane route, due to the high volumes of commercial traffic passing through the area. Multiple methods have been proposed, including a route on the south side over the river and existing route, a route over nearby Little Frog Mountain, and a tunnel.

In 1986, TDOT began preparations to widen the entire segment of US 64 between Memphis and Pelham to four lanes, a distance of about 266 miles (428 km), or about 70% of the length of the route in Tennessee. The final project, in Hardin County, was completed in the fall of 2017.

In November 2009, a massive rock slide closed the Ocoee Scenic Byway for several months. This was reportedly the largest rockslide in the area's history.

US 64 enters Tennessee on the Memphis-Arkansas Bridge in Memphis. The route shares the bridge with Interstate 55 (I-55) and US 61, US 70, US 78, and US 79. The route traverses several streets in Memphis before becoming a rural divided highway in eastern Shelby County. The highway runs directly to the east through the county seats of Tennessee's most southern counties including Oakland, Somerville, Whiteville, Bolivar, Selmer, Adamsville, Savannah, Waynesboro, and Lawrenceburg, the largest on the route between Memphis and I-65. The route then interchanges with I-65, and runs through Fayetteville, Winchester, and comes to an interchange with I-24 near Pelham. The route unofficially runs concurrent with I-24 across Monteagle Mountain, the stretch across the Cumberland Plateau, often cited as one of the most hazardous stretches of highway in the United States and splits at exit 152 near Kimball where it then enters Jasper, becoming concurrent with US 41, of which it crosses Nickajack Lake, part of the Tennessee River to Chattanooga. The route then becomes concurrent with US 11 and runs to Cleveland, where it splits and runs along US 74 into Polk County to the North Carolina state line. The section beginning in Cleveland and continuing into North Carolina is part of Corridor K of the Appalachian Development Highway System. The easternmost portion of the highway along the Ocoee River is the Ocoee Scenic Byway, a winding, two-lane road through the Ocoee River gorge. The steep terrain around the highway is subject to rockslides. This is one of the only sections of US 64 in Tennessee that is still two lanes.

U.S. Route 64 Bypass
Location	Cleveland, Tennessee
Length	6.6 mi (10.6 km)
Existed	1966–present

A bypass route exists for the route in Cleveland. The east–west route is part of a beltway around the business district known as APD-40, and stretches from I-75 to a cloverleaf interchange with US 64 and SR 60. SR 60 makes up the remainder of the route. Part of the route is controlled access, and an interchange with US 11/64 is located approximately a mile from the western terminus.

County	Location	mi	km	Destinations	Notes
Mississippi River		0.0	0.0	I-55 north / US 61 north / US 64 west / US 70 west / US 78 west / US 79 south – St Louis, MO SR 1 begins	Continuation into Arkansas; western terminus of SR 1
Shelby	Memphis	0.5– 0.7	0.80– 1.1	I-55 south – Jackson, MS	Eastern end of I-55 concurrency; I-55 exits 12A & 12B
		1.3	2.1	US 61 south (S 3rd Street / SR 14 south) – Vicksburg, Brownsville US 78 east (E.H. Crump Boulevard / SR 4 east) – Holly Springs	Eastern end of US 61/US 78 concurrency; western end of SR 4/SR 14 concurrency
		2.2	3.5	Doctor M.L.K. Jr Boulevard / SR 278 west  – Holly Springs	Western terminus of unsigned SR 278; former western terminus of US 78
		2.6	4.2	SR 3 north / SR 14 north (N B.B. King Boulevard/N 2nd Street)	Western end of SR 3 concurrency; eastern end of SR 14 concurrency
		2.9	4.7	US 51 north / SR 1 east (Danny Thompson Boulevard) – Millington	Eastern end of SR 1 concurrency; western end of US 51 concurrency
		4.0– 4.2	6.4– 6.8	I-240 south – Jackson, MS	No direct access to north(west)bound I-240 nor from south(east)bound I-240 (both signed at Madison Avenue); I-240 exit 30
		4.3	6.9	US 51 south / SR 3 south (S Bellevue Boulevard) – Jackson	Eastern end of US 51/SR 3 concurrency; western terminus of unsigned SR 23; western end of unsigned SR 23 concurrency
		6.4	10.3	SR 23 east (Union Avenue) / SR 277 south (East Parkway S)	Eastern end of unsigned SR 23 concurrency; western end of unsigned SR 277 concurrency
		6.9	11.1	US 72 east / SR 57 east (Poplar Avenue) – Collierville	Western terminus of US 72; western end of SR 57 concurrency
		7.5	12.1	Sam Cooper Boulevard east to I-40 / I-240 - Nashville	Western terminus of Sam Cooper Boulevard
		7.7	12.4	SR 1 west (North Parkway) / SR 57 west (N Trezevant Street)	Western end of SR 1 concurrency; eastern end of SR 57 and unsigned SR 277 concurrency; northern terminus of unsigned SR 277
		13.0– 13.2	20.9– 21.2	I-40 west to I-240 west – Little Rock, AR, Jackson, MS	No access to I-40 eastbound; I-40 exit 12A
	Bartlett	17.7	28.5	US 70 east / US 79 north (Summer Avenue/SR 1 east) / SR 15 west (Stage Road) – Arlington	Eastern end of US 70/US 79/SR 1 concurrency; western end of unsigned SR 15 concurrency
		20.2	32.5	SR 177 (Germantown Road) – Germantown, Brunswick
		21.1– 21.4	34.0– 34.4	I-40 – Memphis, Nashville	I-40 exit 18
	Eads	28.0– 28.1	45.1– 45.2	I-269 (Winfield Dunn Parkway) – Arlington, Collierville	I-269 exit 15; Memphis outer beltway
		28.2	45.4	SR 205 (Airline Road) – Collierville, Fisherville, Arlington
Fayette	Hickory Withe	32.1	51.7	SR 196 (Chulahoma Road) – Piperton, Gallaway
	Oakland	36.2	58.3	SR 194 (Church Street) – Macon, Rossville
	Somerville	45.6	73.4	SR 76 (Main Street) – Brownsville, Williston, Moscow
	Laconia	51.0– 51.1	82.1– 82.2	Bridge over the Loosahatchie River
Hardeman	Whiteville	57.8	93.0	US 64 Bus. east (West Main Street)	Western terminus of US 64 Bus
		58.4	94.0	SR 179 west (S Cross Avenue)	Eastern terminus of SR 179
		59.4	95.6	US 64 Bus. west (East Main Street)	Eastern terminus of US 64 Bus
		59.6	95.9	SR 100 east – Toone, Henderson	Western terminus of SR 100
	Bolivar	69.0	111.0	SR 18 south (Tennessee Street) – Hickory Valley, Grand Junction	Western end of SR 18 concurrency
		69.7	112.2	SR 18 north / SR 125 (Main Street) – Middleton, Toone	Eastern end of SR 18 concurrency
	​	73.6– 73.7	118.4– 118.6	Bridge over the Hatchie River
McNairy	​	83.7	134.7	SR 225 north (Woodville Road)	Southern terminus of SR 225
	Selmer	91.5	147.3	US 45 north (Marcus J. Wright Memorial Highway/SR 5) / US 64 Bus. east (W Cherry Avenue/SR 15) – Henderson, Bethel Springs, Downtown	Interchange; western end of US 45 concurrency; western terminus of US 64 Bus
		95.5	153.7	US 45 south (Marcus J. Wright Memorial Highway/SR 5) / US 64 Bus. west (W Cherry Avenue/SR 15) – Eastview, Corinth, Downtown	Eastern end of US 45 concurrency; eastern terminus of US 64 Bus
	​	104.8	168.7	Airport Road  – Robert Sibley Airport
	​	108.7	174.9	SR 224 south (Gilchrist Stantonville Road) – Stantonville, Michie	Western end of SR 224 concurrency
	​	109.9	176.9	SR 224 north (Leapwood Enville Road) – Enville	Eastern end of SR 224 concurrency
	Adamsville	111.8	179.9	SR 22 north / SR 117 south (Maple Street) – Milledgeville, Stantonville	Western end of SR 22 concurrency; northern terminus of SR 117; provides access to Shiloh National Military Park
Hardin	Crump	115.7	186.2	SR 69 north (Morris Chapel Road) – Milledgeville	Western end of SR 69 concurrency
		115.9	186.5	SR 22 south – Shiloh, Michie	Eastern end of SR 22 concurrency; provides access to Shiloh National Military Park
	Savannah	119.3– 119.7	192.0– 192.6	Harrison-McGarity Carpenter Memorial Bridge over the Tennessee River
		119.9	193.0	US 64 Truck east (Water Street)	Western terminus of US 64 Truck
		120.3	193.6	SR 128 south (Pickwick Street) – Walkertown, Pickwick Dam	Western end of SR 128 concurrency; provides access to Pickwick Landing State Park and Pickwick Landing Dam
		120.5	193.9	SR 69 south / US 64 Truck west (Florence Road) to SR 203 – Walkertown, Walnut Grove	Eastern end of SR 69 concurrency; eastern terminus of US 64 Truck
	Olivet	123.0	197.9	SR 226 south (Airport Road) – Savannah-Hardin County Airport, Olivet, Maddox	Northern terminus of SR 226
	​	125.7	202.3	SR 128 north (New Highway 128) – Clifton	Eastern end of SR 128 concurrency
Wayne	Clifton Junction	139.1	223.9	US 641 north (Billy Nance Highway/SR 114) – Clifton	Southern terminus of US 641
	Waynesboro	150.9	242.9	SR 13 (N High Street/Waynesboro Highway) – Collinwood, Linden	Interchange via Access road
		151.0– 151.3	243.0– 243.5	J. H. Haggard Sr. Memorial Bridge over the Green River
		151.5	243.8	– Wayne Medical Center
		152.2	244.9	SR 99 east (Old Highway 64 E) – Hohenwald	Western terminus of SR 99
Wayne–Lawrence county line	​	162.3– 162.6	261.2– 261.7	Natchez Trace Parkway	Interchange / access road
Lawrence	Deerfield	166.6	268.1	SR 240 north – Henryville, Summertown	Southern terminus of SR 240
		172.5	277.6	SR 241 north (Red Hill Center Road) – Henryville	Southern terminus of SR 241
	Lawrenceburg	175.4	282.3	US 64 Bus. east (W Gaines Street)	Western terminus of US 64 Bus; provides access to David Crockett State Park
		176.6	284.2	SR 242 (West Point Road) – Westpoint, Iron City	Interchange; provides access to David Crockett State Park
		178.7– 178.8	287.6– 287.8	Ivan Johnston Bridge over Shoal Creek
		179.4	288.7	New Power House Road - New Shoal Creek Dam
		180.1– 180.6	289.8– 290.6	US 43 (S Locust Avenue/Andrew Jackson Highway/SR 6) – Columbia, Florence	Interchange
		186.9	300.8	US 64 Bus. west (Pulaski Highway) – Lawrenceburg-Lawrence County Airport	Eastern terminus of US 64 Bus
Giles	Pulaski	196.2	315.8	SR 166 north (Campbellsville Road) – Campbellsville, Mount Pleasant	Western end of SR 166 concurrency
		197.4	317.7	SR 15 east / SR 166 south (College Street) – Pulaski	Eastern end of SR 15 / SR 166 concurrency
		199.8	321.5	SR 11 (Minor Hill Highway) – Pulaski, Minor Hill
		200.1	322.0	SR 166 (Bethel Road) – Bethel, Pulaski	Provides access to Abernathy Field
		202.2	325.4	US 31 (Elkton Pike/SR 7) – Columbia, Pulaski, Elkton, Ardmore
		203.9	328.1	SR 15 west (E College Street) – Pulaski	Western end of SR 15 concurrency
	Frankewing	210.8– 211.0	339.2– 339.6	I-65 – Nashville, Huntsville	I-65 exit 14
Lincoln	Boonshill	219.9	353.9	SR 244 north (Boonshill Petersburg Road) – Petersburg	Southern terminus of SR 244
	​	226.8	365.0	SR 273 west (Old Elkton Pike) – Dellrose, Elkton	Western end of unsigned SR 273 concurrency
	Fayetteville	228.4	367.6	US 64 Byp. east (Wilson Parkway) – Winchester	Western terminus of US 64 Bypass; southern bypass of Fayetteville
		229.9	370.0	US 431 / SR 50 west (Main Avenue/SR 273 east) – Lewisburg, Petersburg, Park City, Huntsville	Western end of SR 50 concurrency; eastern end of unsigned SR 273 concurrency
		230.9	371.6	US 231 / US 64 Byp. west (Thornton Taylor Parkway/SR 10) – Shelbyville, Pulaski, Park City, Huntsville	Eastern terminus of US 64 Bypass; southern bypass of Fayetteville
		232.4	374.0	SR 50 east (Lynchburg Highway) – Lynchburg	Eastern end of SR 50 concurrency
	Kelso	235.5– 235.8	379.0– 379.5	Donny Ray Hudson Memorial Bridge over the Elk River
	​	241.0	387.9	SR 275 west (Flintville Road) – Flintville	Eastern terminus of SR 275
	​	243.9	392.5	SR 121 south (Elora Road) – Elora	Western end of SR 121 concurrency
	​	244.1	392.8	SR 121 north (Shady Grove Road) – Broadview	Eastern end of SR 121 concurrency; provides access to Tims Ford Dam/Lake
Franklin	Huntland	250.2	402.7	SR 122 west (Main Street) – Huntland	Eastern terminus of SR 122
	Winchester	260.5	419.2	US 64 Bus. (Rowe Gap Road/1st Avenue/SR 15 east) / SR 16 – Winchester, Hytop, AL, Skyline, AL	Partial interchange; eastern end of unsigned SR 15 concurrency; western end of unsigned SR 433 concurrency; southern terminus of unsigned SR 433
		264.2– 264.6	425.2– 425.8	US 41A (Cowan Highway/SR 15) – Winchester, Decherd, Tullahoma, Cowan	Interchange; provides access to Winchester Municipal Airport
	Decherd	268.5– 269.2	432.1– 433.2	SR 50 west (Nissan Powertrain Drive) – Decherd	Interchange; northern terminus of unsigned SR 433; western end of SR 50 concurrency
Franklin–Coffee county line	Alto	278.2– 278.3	447.7– 447.9	Bridge over the Elk River
Coffee	No major junctions
Grundy	Pelham	279.2	449.3	I-24 west / SR 50 west (Payne Cove Road) – Nashville, Pelham	Western end of I-24 concurrency; eastern end of SR 50 concurrency; I-24 exit 127
Marion	Monteagle	286.0	460.3	US 41A (W Main Street/SR 15) – Monteagle, Sewanee	I-24 exit 134
		287.1	462.0	To US 41 north (SR 2 west/Dixie Lee Avenue) – Monteagle, Tracy City	Western end of SR 2 concurrency; I-24 Exit 135
	​	294.3– 294.5	473.6– 474.0	SR 2 east (Martin Springs Road)	Eastern end of SR 2 concurrency; I-24 Exit 143
	Kimball	303.4– 303.9	488.3– 489.1	I-24 east / US 72 west (N Cedar Avenue/SR 27) – Chattanooga, South Pittsburg	Eastern end of I-24 concurrency; western end of US 72/SR 27 concurrency; I-24 exit 152
		304.0	489.2	SR 2 west (Battle Creek Road)	Western end of SR 2 concurrency
	Jasper	308.8– 308.9	497.0– 497.1	US 41 north / SR 28 (SR 27) – Whitwell, Tracy City	Interchange; western end of US 41 concurrency; eastern end of SR 27 concurrency
		309.5– 309.6	498.1– 498.3	Marion County Veterans Bridge over the Sequatchie River
	​	312.0	502.1	SR 27 (Griffin Highway) – Marion County-Brown Field, Powells Crossroads
	Haletown	314.1– 314.4	505.5– 506.0	Marion Memorial Bridge over the Tennessee River/Nickajack Lake
		314.6	506.3	SR 134 east (J E Clouse Highway) – Whiteside	Western terminus of SR 134
Hamilton	Lookout Valley	328.9– 329.0	529.3– 529.5	I-24 – Chattanooga, Nashville	I-24 exit 174
		329.2	529.8	US 11 south (Birmingham Highway/SR 38)	Western end of US 11 concurrency; northern terminus of unsigned SR 38
		330.7	532.2	SR 318 south (Old Wauhatchie Pike) – Lookout Mountain	Northern terminus of SR 318
		331.8	534.0	SR 148 south (Lookout Mountain Parkway) – Lookout Mountain	Northern terminus of SR 148
	Chattanooga	332.7	535.4	SR 17 south (Tennessee Avenue) to SR 58 – Lookout Mountain	Western end of SR 17 concurrency
		333.9– 334.1	537.4– 537.7	US 27 north (I-124 north/SR 27 west/SR 29 north) – Red Bank, Downtown	No direct access to westbound I-24; northbound exit and southbound entrance from US 27
		334.2	537.8	US 41 north / US 72 east / SR 17 north (Broad Street) / SR 58 north (W 20th Street)	Eastern end of US 41 / US 72 / SR 17 concurrency; western end of SR 58 concurrency
		334.5	538.3	SR 58 south (Market Street)	Eastern end of SR 58 concurrency
		335.3	539.6	I-24 west – Nashville, Birmingham	Direct access only from eastbound I-24; I-24 exit 180A
		336.9	542.2	US 41 south (Westside Drive/SR 8) / US 76 west – East Ridge	Western end of US 41 / US 76 concurrency
		337.4	543.0	US 41 north / US 76 west (E Main Street/SR 8)	Eastern end of US 41 / US 76 concurrency
		338.4– 338.6	544.6– 544.9	McCallie Tunnels under Missionary Ridge
		342.0	550.4	SR 320 east (East Brainerd Road) – East Brainerd	Western terminus of SR 320
		343.7– 343.8	553.1– 553.3	SR 153 – Soddy-Daisy, Falling Water	SR 153 exit 1
		347.1	558.6	SR 317 west (Bonny Oaks Drive) – Tyner	Western end of SR 317 concurrency
		347.2– 347.5	558.8– 559.2	I-75 south / US 74 west – Atlanta	Western end of I-75/US 74 concurrency; I-75 exit 7
		348.7– 349.3	561.2– 562.1	SR 317 east (Apison Pike) – Ooltewah, Collegedale	Eastern end of SR 317 concurrency; I-75 exit 9
	Ooltewah	351.4	565.5	I-75 north / US 74 east – Knoxville	Eastern end of I-75 / US 74 concurrency; I-75 exit 11
		352.2	566.8	SR 321 south (Main Street) – Collegedale, East Brainerd	Northern terminus of SR 321
Bradley	Cleveland	361.8– 362.0	582.3– 582.6	US 74 / US 64 Byp. (APD-40/SR 311)	Interchange
		364.3	586.3	US 11 Byp. north (Keith Street/SR 2) SR 40 begins	Eastern end of unsigned SR 2 concurrency; southern terminus of US 11 Bypass; western terminus of unsigned SR 40; western end of unsigned SR 40 concurrency
		365.0	587.4	US 11 north (Broad Street/Ocoee Street/SR 74 north) / SR 312 east (Inman Street)	Western end of SR 74 concurrency; eastern end of US 11 concurrency; eastern terminus of SR 312
		365.4	588.1	SR 60 south / SR 74 south (Wildwood Avenue) – Wildwood Lake, Dalton, GA	Eastern end of SR 74 concurrency; western end of SR 60 concurrency
		366.6– 367.0	590.0– 590.6	US 74 west / US 64 Byp. end / SR 60 north (APD-40/SR 311)	Interchange; eastern end of SR 60 concurrency; western end of US 74 concurrency
Polk	Ocoee	374.3	602.4	US 411 (SR 33) – Benton, Chatsworth, Georgia	Interchange
	Parksville	378.7	609.5	SR 314 north (Parksville Road) – Benton	Southern terminus of SR 314
	Cherokee National Forest	383.9	617.8	SR 30 west – Reliance	Eastern terminus of SR 30
	Ducktown	400.1– 400.4	643.9– 644.4	SR 68 – Copperhill, Ducktown	Interchange
North Carolina state line		404.1	650.3	US 64 east / US 74 east – Murphy	Continuation east into North Carolina; eastern terminus of unsigned SR 40
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access

State Route 40
Route information
Maintained by TDOT
Length	39.63 mi (63.78 km)
Existed	October 1, 1923–present
Location
Country	United States
State	Tennessee
Counties	Bradley and Polk
Highway system
Tennessee State Routes Interstate US State
← I-40 → US 41

State Route 40 (SR 40) runs as a secret, or hidden designation for US 64/US 74 from downtown Cleveland, in Bradley County to the North Carolina state line near Ducktown, in Polk County. SR 40 was also a former designation for part of APD-40, which is the origin of part of the common name of that route. State Route 40 becomes secondary east of its intersection with SR 60 in Cleveland.

State Route 433
Location	Winchester-Decherd, Tennessee
Length	8.2 mi (13.2 km)

State Route 433 (SR 433) is the unsigned designation for US 64’s southern and eastern bypass of the cities of Winchester and Decherd in Franklin County, Tennessee. The entire route is a four-lane divided highway (which is known locally as Veterans Memorial Drive), with interchanges at SR 16 (1st Avenue/Rowe Gap Road), US 41A (S College Street/Cowan Highway), and SR 50 (Nissan Powertrain Drive).

Media related to U.S. Route 64 in Tennessee at Wikimedia Commons

U.S. Route 64
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