State Route 80 (SR 80) is a north–south state highway in Middle Tennessee. The 13.8 miles (22.2 km)-long road traverses portions of Smith and Macon Counties.

SR 80 begins in Smith County just west Carthage at an intersection with SR 25 on the banks of the Cumberland River. It then goes north as a 2-lane country road, having an intersection with SR 85, about 2 miles west of Defeated, just after passing through Monoville. It the passes through some rolling hills and farmland before passing through Pleasant Shade. It then crosses into Macon County shortly afterwards. It then winds through some more hills before having an intersection with Defeated Creek Road, a back road to Defeated. SR 80 then ends at a 4-way stop intersection with SR 56 and SR 262 in Willette.

County	Location	mi	km	Destinations	Notes
Smith	​	0.0	0.0	SR 25 (Dixon Springs Highway) – Carthage, Hartsville	Southern terminus
	Monoville	2.5	4.0	SR 85 east (Defeated Creek Highway) – Defeated, Gainesboro	Western terminus of SR 85
Macon	Willette	13.8	22.2	SR 56 / SR 262 (Union Camp Road/Carthage Road/Willette Road) – Lafayette, Red Boiling Springs, Gainesboro	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• U.S. Roads portal