Tenth Presbyterian Church is a congregation of approximately 1,600 members located in Center City, Philadelphia, Pennsylvania, United States. Tenth is a part of the Presbyterian Church in America (PCA), a denomination in the Reformed (Calvinist) tradition. It is located at the southwest corner of 17th & Spruce Streets in Philadelphia's Rittenhouse Square neighborhood, in the southwestern quadrant of Center City.

The original Tenth Presbyterian Church, founded in 1829 as a congregation part of the Presbyterian Church in the United States of America, was located on the northeast corner of 12th & Walnut Streets. It established a daughter church in 1855–1856 called the West Spruce Street Presbyterian Church on the southwest corner of 17th & Spruce Streets. The two churches worked together, with the ministers exchanging pulpits each week. Because of membership decline in the original Tenth Church caused by population shifts, the two churches merged in 1893 at the 17th & Spruce Streets location, taking the name of the older church (Tenth Presbyterian Church).

West Spruce Street/Tenth Church was designed by architect John McArthur Jr., who was a member of the congregation. Its 250-foot (76 m) tower-and-spire was the tallest structure in Philadelphia from 1856 to the erection of the tower of Philadelphia City Hall in 1894, also designed by McArthur. In 1893, architect Frank Miles Day was hired to perform major alterations to the church's exterior and interior decoration. The church's steeple with its 150-foot wooden spire was weakened due to structural decay of the timber frame, and was removed in 1912 due to fears that it would collapse.

The Philadelphia Presbytery (PC-USA) was a conservative bastion during the fundamentalist-modernist controversy of the 1920s and 1930s, and Tenth Presbyterian was no exception. Under the influence of longtime pastor Donald Barnhouse (1927–1960), the congregation became the conservative Presbyterian church in Center City, and it has remained a conservative and evangelical congregation until this day. Under James Montgomery Boice (1968–2000), the congregation continued to be a center of conservative Reformed theology. Tenth membership continued to grow after World War II, and ministry efforts to college students gave the congregation a metropolitan focus.

Under Boice's pastorate, Tenth grew from 350 members to a congregation over 1,200.

In 1979, following a denominational ruling by the United Presbyterian Church in the United States of America requiring congregations to elect both men and women as ruling elder, Tenth Presbyterian left the UPCUSA in 1980, joining the more conservative Reformed Presbyterian Church, Evangelical Synod. Three years afterward, Tenth followed the RPCES into the Presbyterian Church in America, a church of Southern origin.

After a lengthy property battle, the congregation was allowed to leave the UPCUSA while keeping its Byzantine-style property. Tenth Presbyterian is considered the "big-steeple" PCA congregation in the northeastern United States. The church sponsors an extensive global missions program, and an outreach to the neighborhood includes a strong connection to the rising generation of doctors, interns, and residents attending the medical schools in the neighborhood.

In December 1, 2023, Tenth Presbyterian senior pastor Rev. Dr. William "Liam" Goligher resigned, nine years after pleading guilty to "personal conduct" charges in a park in Lancaster, Pennsylvania, charges disclosed by church watchdog group Anglican Watch. On May 20, 2024 the Philadelphia Presbytery Presbyterian Church in America suspended Liam Goligher indefinitely for contumacy - defined by the Presbyterian Church in America as refusing to cooperate in church disciplinary proceedings.

Some notable staff members of the church from its founding include:

• Thomas McAuley, D.D., LL.D. Senior Pastor. 1829–1833
• Henry Augustus Boardman, D.D. Senior Pastor. 1833–1876
• Marcus A. Brownson, D.D. Senior Pastor. 1897–1924
• Donald Grey Barnhouse, Th.D., D.D. Senior Pastor. 1927–1960
• Mariano Di Gangi, D.D. Senior Pastor. 1961–1967
• James Montgomery Boice, Th.D., D.D. Senior Minister. 1968–2000
• Philip G. Ryken, DPhil. Senior Minister. 1995–2010, now president of Wheaton College
• William "Liam" W. Goligher, D.Min. Senior Minister. May 22, 2011 – December 1, 2023, born in Glasgow, Scotland.
• Jonathan "Jonny" Gibson, PhD. Stated Supply Senior Minister. October 6, 2024 - present, born in Northern Ireland, con-currently serving as Associate Professor of Old Testament at Westminster Theological Seminary.

Some notable members have included:

• C. Everett Koop, MD Surgeon General of the United States served during the Presidency of Ronald Reagan and provided guidance during the onset of the global HIV/AIDS pandemic. He first gained national attention as the head of pediatrics at the University of Pennsylvania and Children's Hospital of Philadelphia. A plaque in the sanctuary notes his membership and service to the country.

• Three Sunday services with approximately 1,400 people in weekly attendance
• ACTS Ministries: mercy ministries to the poor and homeless near Tenth Church
• Tenth College Fellowship (TCF) is a group for college students.
• Tenth City Network (TCN) is a group for young adults.
• Maranatha is the youth group for students in grades 7–12, begun in 1984 and still continuing to meet weekly on Sunday nights and sponsor other events throughout the year.
• Small group Bible studies meet weekly in host homes across the city of Philadelphia and throughout the suburbs in Pennsylvania and New Jersey
• Various other discipleship groups, support groups, and prayer groups meet regularly in the church facilities and elsewhere

• Tenth Presbyterian Church Architecture
• 
  Steeple of church and north side exterior
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  Pulpit, platform by architect Frank Miles Day in Neo-Byzantine style
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  Apse and rear of sanctuary in Neo-Byzantine style with organ in the back
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  Stained glass window of angel on east side of sanctuary with folded glass
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  Scottish Presbyterian, French Huguenot stain glassed window
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  Memorial plaque in sanctuary
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  Memorial plaque in sanctuary by Theophilus P. Chandler Jr.
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  Arched Lombard Romanesque doors with pilasters and Church's logo on top
• 
  Main entrance on north side of church in Lombard Romanesque style

• Official website
• Tenth Presbyterian Church – at Philadelphia Architects and Buildings

Records
Preceded by Park Street Church	Tallest towers in the United States outside of New York City 1856–1863 76 m	Succeeded by United States Capitol
Preceded by Christ Church	Tallest building in Pennsylvania 76 metres (249 ft) 1856-1894	Succeeded by Philadelphia City Hall
Preceded by Christ Church	Tallest building in Philadelphia 76 metres (249 ft) 1856-1894	Succeeded by Philadelphia City Hall