Loop 499 is a 7.868-mile-long (12.662 km) loop route around the city of Harlingen in the U.S. state of Texas. The loop extends around the northern, eastern, and southern sides, with Interstate 69E, U.S. Highway 77, and 83 completing the loop on the west side. This loop was proposed and temporarily designated in 1971 at the beginning of construction, with official designation in 1973. The loop is a significant thoroughfare around the city, as it is the main connection to Valley International Airport.

Loop 499 begins on the north side of Harlingen at I-69E/US 77. It heads east from this junction to FM 507. The loop begins to curve to the south at this intersection as it passes to the southwest of Valley International Airport. Heading south through the east side of Harlingen, the loop intersects Spur 206 and FM 106 at Harrison Avenue. The highway curves towards the southwest after this intersection and continues to the southwest to a junction with U.S. Highway 77 Business near Valley Baptist Memorial Hospital. The loop continues to the southwest ending at an interchange with I-69E/US 77/US 83.

Loop 499 was given a temporary designation on April 29, 1971 until construction began on the highway. On April 31, 1973, it was officially added to the State Highway System as a route from US 77 to Loop 448. The route was extended to the southwest to US 83 over a section of Farm to Market Road 801 on May 21, 1979.

The entire route is in Harlingen, Cameron County.

mi	km	Destinations	Notes
0.000	0.000	I-69E / US 77 / US 83	I-69E exit 23A
		Bus. US 77 (Sunshine Strip)
		FM 507 (25th Street)
		Spur 206 / FM 106 (Harrison Avenue)
		Bus. US 77 (Sunshine Strip)
7.868	12.662	I-69E / US 77	I-69E exit 29A
1.000 mi = 1.609 km; 1.000 km = 0.621 mi