That Phanom (Thai: ธาตุพนม, pronounced [tʰâːt pʰā.nōm]) is a district (amphoe) in the southern part of Nakhon Phanom province, northeastern Thailand.

The district is named after Wat Phra That Phanom, the most important Buddhist temple in the region.

Neighboring districts are (from the south clockwise) Wan Yai, Mueang Mukdahan, Dong Luang of Mukdahan province, Na Kae, Renu Nakhon, and Mueang Nakhon Phanom of Nakhon Phanom Province. To the east across the Mekong River is the Laotian province Khammouan. Elevation between 142 and 252 meters (830 feet).

In 1917, the district name was changed from Renu Nakhon (เรณูนคร) to That Phanom.

The district is divided into 12 sub-districts (tambons), which are further subdivided into 142 villages (mubans). The sub-district municipality (thesaban tambon) That Phanom covers parts of tambon That Phanom and That Phanom Nuea. There are a further 11 tambon administrative organizations (TAO).

No.	Name	Thai	Villages	Pop.
01.	That Phanom	ธาตุพนม	19	11,238
02.	Fang Daeng	ฝั่งแดง	11	06,963
03.	Phon Phaeng	โพนแพง	08	04,862
04.	Phra Klang Thung	พระกลางทุ่ง	16	07,598
05.	Na Thon	นาถ่อน	15	08,729
06.	Saen Phan	แสนพัน	08	04,002
07.	Don Nang Hong	ดอนนางหงส์	11	06,837
08.	Nam Kam	น้ำก่ำ	20	12,160
09.	Um Mao	อุ่มเหม้า	09	05,463
10.	Na Nat	นาหนาด	10	05,515
11.	Kut Chim	กุดฉิม	07	04,448
12.	That Phanom Nuea	ธาตุพนมเหนือ	08	05,663

The district's location on a bank of the Mekong has made it a prime agricultural area. Tomatoes, in particular, are one of the more profitable crops.

That Phanom is also the only one in the northeastern where scrap metal or discarded metal is processed into machetes. It is classified as a community enterprise that generates income of up to 30–40 million baht per year.

• amphoe.com (Thai)