Thomas Jefferson High School is a secondary school located in the Southmoor Park neighborhood, on the southeast side of Denver, Colorado, United States. It is operated under the Denver Public Schools. The school teams are the Spartans. The school and its athletic fields are undergoing significant renovations, both of which were built in 1960.

The school offers Advanced Placement classes in English, mathematics, science, social studies, and Spanish. It also hosts a gifted program in various areas of study, such as the Computer Magnet Program, JROTC, concurrent enrollment and X-Track courses.

Thomas Jefferson's programs include a student-run newspaper, student-run newscasting, Computer Magnet Program (CCT), yearbook assembled in-house, diversity club, National Honor Society, and DECA.

As of 2021–2022 1,374 students were enrolled.

• 473 White
• 258 African American
• 47 Asian
• 7 Native American
• 6 Hawaiian Native/Pacific Islander
• 497 Latino or Hispanic
• 86 Two or More Races
• 634 Female
• 740 Male

Using federal government guidelines, 47% of the students were eligible for free or reduced-price lunch.

This article's list of alumni may not follow Wikipedia's verifiability policy. Please improve this article by removing names that do not have independent reliable sources showing they merit inclusion in this article AND are alumni, or by incorporating the relevant publications into the body of the article through appropriate citations. (June 2022)

• Pierre Allen - (b 1987) retired NFL football defensive end.
• Michael Dinner - (b 1953) director, producer, and screenwriter for television. '80s hit The Wonder Years.
• Kyle Freeland - (b 1993) is a professional baseball pitcher for the Colorado Rockies
• Malcom Glenn - (b 1987) is a writer and speaker and was The President of The Harvard Crimson
• Daniel Graham - (b 1978) is a former NFL tight end for Denver Broncos
• Jim Gray - (b 1959) is a sportscaster currently with Showtime
• Tyler Green - (b 1970), is a former MLB pitcher, who played for Philadelphia Phillies
• Brad Handler - (b 1967) is an entrepreneur and attorney.
• Brent Handler - (b 1969) is an entrepreneur who works in the destination club industry.
• Kristina M. Johnson - (b 1957) is an American business executive, engineer, academic, and former government official.
• Chaney Kley - (1972-2007) was an actor known for his role in Darkness Falls.
• DeWayne Lewis - (b 1985) is an NFL cornerback who played for Cincinnati Bengals.
• Derrick Martin - (b 1985) is an NFL safety who played for Baltimore Ravens.
• Jovan Melton - Colorado State Representative - House District 41, House Majority Deputy Whip
• John Stearns - (1951–2022), nicknamed "Bad Dude", was a All-Star MLB professional baseball catcher and coach for the New York Mets.
• John Trahan - (b 1961), is a former NFL wide receiver for Kansas City Chiefs
• Barney Visser - (b 1949) is an entrepreneur and author and owner and driver in NASCAR
• Michael Winslow - (b 1958) is an actor, comedian and beatboxer known for the Police Academy films.
• Andre Woolfolk - (b 1980) is a retired NFL cornerback for the Tennessee Titans.
• Leni Wylliams - (1961–1996) was a dancer, choreographer, artistic director and master teacher.
• Wendy Lucero-Schayes - (b 1963) is a former Olympic diver and TV commentator.
• George DiCarlo - (b 1963) is a former Olympic Gold Medalist swimmer.

• Official site