Toototobi River is a river in the Amazon Rainforest of Amazonas, Brazil. It is a tributary of the upper Rio Demini near the headwaters of the Orinoco.

The river flows through the territory of Kopenawa near the border of Venezuela. The so-called "Toototobi Yanomami índios" take their name from this river. Davi Kopenawa Yanomami, a shaman and Portuguese-speaking spokesperson of that tribal group, was born close to it. The area may be a starting point for the epidemics of measles and other diseases which decimated the local peoples starting in the 1970s.

• [1] "Engagement of anthropologists in public dialogue with members of study communities", University of Arizona
• [2] Report of the Medical Team of the Federal University of Rio de Janeiro on Accusations Contained in Patrick Tierney's Darkness in El Dorado
• [3] When Did the Measles Epidemic Begin among the Yanomami?

1°34′N 63°33′W / 1.567°N 63.550°W / 1.567; -63.550