The Tsitsikamma River (Afrikaans: Tsitsikammarivier) is a small river at the western end of the Eastern Cape coast, South Africa. It is part of the Fish to Tsitsikama Water Management Area.

It is a small permanent river that has its sources in the Tsitsikamma Mountains. Initially it flows southwards, then it flows southeastwards, parallel to the coast for most of its course, bending southwestwards only 3 km from its mouth in Huisklip Beach.

• Tsitsikamma National Park
• List of rivers of South Africa
• List of reservoirs and dams in South Africa

• Tsitsikamma National Park
• Tsitsikamma River Research