On November 10, 2024, one person was killed and 16 others were injured in a mass shooting at Tuskegee University. One person was later arrested, who was in possession of a semi-automatic pistol with a machine gun conversion device. The attack occurred on Sunday morning of the university's homecoming weekend.

There had been a series of mass shootings associated with homecoming events throughout the country. On October 12, one person was killed and nine others were injured near the campus of Tennessee State University in Nashville following a homecoming football game as crowds left the match when two groups of people opened fire on each other. On October 19, a 19-year-old woman was killed and four others were wounded on the campus of Albany State University in Albany, Georgia during homecoming weekend celebrations. On the same day, three people were killed and eight others were injured on a trail near Lexington, Mississippi during a post-homecoming football game celebration for Holmes County Central High School. On October 26, shots were fired into the air on the campus of North Carolina Central University in Durham during the school's homecoming celebration, which caused a lockdown, and as officers swept the campus for threats another unrelated shooting began in which four people were wounded.

On November 3, during a homecoming party for Oklahoma State University students at an event venue in Stillwater, four people were wounded when at least one person opened fire. On November 9, two people were killed and two others were injured near the University of Louisiana in Lafayette just after a homecoming game.

The shooting occurred at the end of the University's 100th Homecoming weekend at the West Commons on-campus apartments during a party at around 1:40 a.m. on November 10. Video of the shooting posted later to social media shows people ducking for cover in a parking lot as shots are heard, and an eyewitness stated he crawled under his car and then ran to his dorm.

An 18-year-old male not affiliated with the university was killed and 16 others were injured, one critically. Four of the injuries were not gunshot-related. Victims were transported to and treated at the East Alabama Medical Center in Opelika and the Baptist South Hospital in Montgomery.

The suspect, 25-year-old Jaquez Myrick of Montgomery, Alabama, was arrested and charged federally with possession of a machine gun. Law enforcement officers found him leaving the scene of the shooting at the time of his arrest.

The university canceled classes on Monday, November 11, and announced grief counselors would be available to students. The campus was closed after the shooting, with students and faculty having to wear their ID's while on campus. The university also fired the campus security chief and a new security chief will conduct a review of the shooting.

The Tuskegee police chief Patrick Mardis, stated that "Some idiots started shooting."