Tyro Mill is a historic grist mill located at Tyro, Nelson County, Virginia. It is a multi-story frame mill built in 1846–47 with an addition made in the late nineteenth century. It has a metal-sheathed gable roof and a stone foundation. There is an overshot metal wheel in a stone wheel well and remnants of the head race. The mill contains original machinery including wood gears and drive shafts, two runs of millstones, and a husk frame in the basement gear pit. Also on the property is a mid-19th century log dwelling—traditionally identified as the miller's house—with twentieth century frame additions and front porch.

It was listed on the National Register of Historic Places in 2006.