U.S. Route 383 was a north–south United States highway. US 383 was created in 1942, and deleted in 1982. After deletion, a portion of the highway became K-383.

US-383 began in Oakley, heading north along present-day US-83. A short distance north of Oakley, the route intersected I-70. In Halford, US-83/US-383 crossed over US-24. From here, the road turned northeast, where US-383 split from US-83 near Leoville. US-383 continued to the northeast until meeting US-36. At this point, the route turned east for a concurrency with US-36, crossing US-283 in Norton. Past Norton, US-383 split from US-36 and resumed northeast, reaching an intersection with US-183 near Woodruff a short distance south of the Nebraska border.

In Nebraska, US-383 continued north on the present alignment of US-183, reaching an intersection with US-136 in Alma. Prior to 1964, US-383 continued north past Alma, intersecting US-6/US-34 in Holdrege before ending at US-30 in Elm Creek.

When the route was first commissioned in 1942, it ran from Oakley, Kansas to Elm Creek, Nebraska, a distance of 175 miles (282 km). In 1964, the north end of US 383 was truncated to Alma, Nebraska.

State	County	Location	mi	km	Destinations	Notes
Kansas	Logan	Oakley	0	0.0	US 40 / US 83 south – Sharon Springs, Wakeeney	Southern end of US 83 overlap
	Thomas	​	20	32	US 24 – Colby, Hoxie
	Sheridan	​	44	71	US 83 north / K-23 south – Hoxie, Oberlin	Northern end of US 83 overlap
	Decatur	Dresden	53	85	K-123 south
	Norton	​	90	140	US 36 west – Oberlin	Southern end of US 36 overlap
		Norton	96	154	US 283 – Hill City, Arapahoe Neb.
		​	99	159	K-67 north – Norton Correctional Facility
		Calvert	102	164	US 36 east – Phillipsburg	Northern end of US 36 overlap
		​	107	172	K-60 south
	Phillips	​	138	222	US 183 south – Phillipsburg	Southern end of US 183 overlap
			139 0	224 0.0	Kansas–Nebraska state line
Nebraska	Harlan	​	4	6.4	N-89 – Orleans
		Alma	7	11	US 136 east – Franklin	Southern end of US 136 overlap; former N-3 east; northern end of the route after 1964
			9	14	US 136 west – Orleans	Northern end of US 136 overlap; former N-3 west
		​	14	23	Spur 2183 east – Huntley
		​	21	34	N-4 to US 6 / US 34 – Beatrice
	Phelps	Holdrege	31	50	US 6 / US 34 east – Minden	Southern end of US 6/US 34 overlap
			32	51	US 6 / US 34 west – Arapahoe	Northern end of US 6/US 34 overlap
	Buffalo	Elm Creek	51	82	US 183 north / US 30 (Lincoln Highway) – Kearney, Lexington, Miller	Original northern terminus; northern end of US 183 overlap
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• U.S. Route 83
• U.S. Route 183
• U.S. Route 283
• K-383

• Historic endpoints of U.S. Highway 383