U.S. Route 49 (US 49) is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.

It was at the junction of US 49 and U.S. Route 61 that blues singer Robert Johnson is said to have sold his soul to the Devil. The highway is also the subject of songs by Big Joe Williams and Howlin' Wolf (Chester Arthur Burnett).

Lengths

	mi	km
MS	334	538
AR	182	293
Total	516	830

US 49 has historically been one of the most important highways in Mississippi. It was the state's first highway to see a significant rural segment four-laned. Today, it is the only four-laned route directly connecting Jackson, the state's capital and largest city, to the Mississippi Gulf Coast. Some urban segments along this portion of the route maintain three or more traffic lanes in each direction. US 49 serves as a primary hurricane evacuation route for Gulf Coast residents.

US 49 begins near the Port of Gulfport, Mississippi at a junction with US 90. It provides a major connection between the port, casinos, beaches and downtown with I-10 (exits 34A-B), where it has its first major junction being a full service cloverleaf interchange on the city's north end. The crossing of these two roads is officially recognized by the state of Mississippi as the Castilgia Interchange. North of I-10, US 49 passes through suburban areas and enters De Soto National Forest. Various state highway interchanges and junctions are encountered before the route passes near Camp Shelby, then through an interchange with US 98 just south of Hattiesburg. At this point, travelers have an option of continuing on US 49 through Hattiesburg or using the I-59/US 98 bypass which reconnects with US 49 in the northern part of the city. Continuing on US 49 brings one to a cloverleaf interchange at US 11, one of very few in the South to lack merging lanes between loop ramps, thus altering the usual weaving patterns which plague many of these interchanges.

US 49 passes Hattiesburg's primary medical facility, Forrest General Hospital, and the campus of the University of Southern Mississippi before arriving at another, more standard cloverleaf interchange with I-59. Those who used the aforementioned bypass, wishing to reconnect with US 49 North to the state capital, must use exit 67B. It is also at I-59, where Mississippi Highway 42 (MS 42) runs with US 49 for a short distance as suburban development is soon encountered as the road returns to rural environs. Eventually, MS 42 departs from the four-laned highway and branches off to the west toward smaller towns, starting with Sumrall. Interchanges between Hattiesburg and Jackson provide access to various state highways, and one at Collins provides access to US 84.

At Jackson, US 49 upgrades to Interstate Highway standards before joining I-20 using a two-lane flyover. About a mile later, I-20/US 49 merges with I-55 at a stack interchange. I-20/I-55/US 49 crosses the Pearl River into Hinds County and bypasses Downtown Jackson, where I-55 departs to the south. US 49/I-20 continue west until US 49 ends its run with I-20 and joins I-220 before turning northwest to Yazoo City. A split in the highway, rare in the U.S. Highway System, begins here; both routes head into the Mississippi Delta, US 49W serving the towns of Belzoni and Indianola, where it junctions with US 82 and its four-lane segment ends, while two-laned US 49E serves Tchula before encountering US 82 at Greenwood. Both routes continue north from US 82 and are linked again at Tutwiler. Continuing northwest, the highway passes through an interchange with US 61 as it enters Clarksdale. It is at Clarksdale that US 49 encounters "The Crossroads", the legendary junction with State Street (an old alignment of US 61) where the great blues musician Robert Johnson is reputed to have sold his soul to the devil.

From Clarksdale, US 49 continues north and crosses the Mississippi River using the Helena Bridge where it enters Arkansas near the town of Helena.

In May 2005 portions of extant US 49E were renamed the "Emmett Till Memorial Highway".

The Mississippi section of US 49 and the routes of US 49E and US 49W are defined at Mississippi Code Annotated § 65-3-3.

US 49 enters Arkansas near Helena-West Helena in Phillips County. US 49 Business runs around the north part of the city, with the main route meeting AR 242 in the southern portion. US 49 continues west to Walnut Corner where the route meets AR 1 (and briefly AR 316). The US 49/AR 1 concurrency ends in Marvell and US 49 enters Monroe County.

Upon entering Monroe County, US 49 turns north to begin a concurrency with AR 39. US 49 also crosses US 79 before meeting US 70 near Brinkley. The route crosses Interstate 40 north of Brinkley prior to entering Woodruff County. US 49 runs northeast through rural Woodruff County, not crossing of concurring with any important routes before crossing into Cross County.

The route meets US 64 in Fair Oaks and meets AR 42 in southern Hickory Ridge. It then enters Poinsett County, concurring with AR 214 from Fisher until Waldenburg. The route crosses AR 14 in Waldenburg.

US 49 runs along south Jonesboro, with US 49 Business formerly running into town. US 49 concurs with US 63 until again joining AR 1. The two routes angle north through downtown Jonesboro, crossing US 63 Business and passing by ASU Stadium before leaving town. US 49/AR 1 pass around Brookland, with US 49 Business serving the community.

Entering Greene County, US 49/AR 1 intersects US 412 and briefly meets AR 358 before entering Paragould. The routes cross US 412B near Kirk Field in Paragould, also meeting AR 135 north of town. US 49B also rejoins US 49/AR 1 north of Paragould.

Continuing northeast through rural Greene County, US 49/AR 1 meet AR 34 in Marmaduke and AR 90 in Rector. The route turns north to Piggott at Hargrave Corner, terminating at US 62/AR 139. The Arkansas portion of US 49 is mainly two-lane undivided.

One of the original US highways, US 49 was extended north from Clarksdale, Mississippi to US 70 in Brinkley, Arkansas via U.S. Route 61 and Highway 6 in 1963. US 49 was again extended north in 1978, replacing Highway 39 between Brinkley and Jonesboro. Highway 1 between Jonesboro and Piggott was redesignated as US 49 in 1979.

It is notable that for several years during the 1930s, a second split route existed on US 49 in South Mississippi, similar to but shorter than the split that still exists in the Delta region. Between Brooklyn and Hattiesburg, travelers had the option of a 24-mile-long (39 km) direct route via US 49W, or a somewhat shorter but broken route on US 49E, serving the Forrest County Agricultural High School and the small community of McLaurin, Mississippi.

State	County	Location	mi	km	Exit	Destinations	Notes
Mississippi	Harrison	Gulfport	0.00	0.00		US 90 – Biloxi, Long Beach, Ship Island Ferry	Southern terminus
			4.4– 4.9	7.1– 7.9		I-10 – New Orleans, Biloxi, Mobile	Exits 34A-B on I-10
			9.4	15.1		MS 53 north – Poplarville, Lyman Fish Hatchery
		​	20.0– 20.6	32.2– 33.2		MS 67 south – D'Iberville, Biloxi	Interchange
	Stone	Wiggins, Stone County	32.9	52.9		MS 149 north to MS 29 – Downtown Wiggins, South Wiggins, Flint Creek Water Park
			34.2– 34.6	55.0– 55.7		MS 26 – Poplarville, Lucedale	Interchange
			36.7	59.1		MS 149 south to MS 29 – Downtown Wiggins, Flint Creek Water Park
	Forrest	​	41.6	66.9		MS 13 north – Lumberton
		​	54.6	87.9		S Lake Drive – Paul B. Johnson State Park	Access road into park
		Hattiesburg	62.3– 62.8	100.3– 101.1		US 98 to I-59 – Columbia, Laurel, Lucedale, Mobile	Interchange
			65.1	104.8		Edwards Street (MS 969 north)
			67.5– 67.9	108.6– 109.3		US 11 (Broadway Drive) – Purvis	Interchange
			69.1	111.2		MS 198 west (Hardy Street) to I-59 / US 98 – Columbia
			70.7	113.8		Old Highway 42 - Petal	Former MS 42 east
			71.6– 72.0	115.2– 115.9		I-59 / MS 42 east – New Orleans, Gulf Coast, Laurel, Airport	Southern end of MS 42 concurrency; exit 67 on I-59
		​	77.5	124.7		MS 42 west – Sumrall, Prentiss	Northern end of MS 42 concurrency
	Covington	​	84.2	135.5		MS 598 east – Sanford
		Seminary	88.9	143.1		MS 589 south – Sumrall
			89.1	143.4		MS 590 east – Seminary
		Collins	95.1– 95.5	153.0– 153.7		MS 184 – Downtown Collins	Interchange
			96.4– 96.7	155.1– 155.6		US 84 – Prentiss, Laurel	Interchange
		​	104.2	167.7		MS 149 north
		Mount Olive	104.7	168.5		MS 35 – Bassfield, Columbia, Mount Olive, Mize
			106.6	171.6		MS 149 south – Mount Olive
	Simpson	Magee	113.4	182.5		MS 149 north
			114.1	183.6		MS 28 east – Mize, Laurel	Southern end of MS 28 concurrency
			114.2	183.8		MS 541 north – Downtown Magee	Southern end of MS 541 concurrency
			114.6	184.4		MS 28 west / MS 541 south – Georgetown, Hazlehurst	Northern end of MS 28/MS 541 concurrency
			117.0	188.3		MS 149 to MS 545 – Boswell Regional Center (Department of Mental Health)	Interchange
		​	119.3	192.0		MS 149 south – Sanatorium
		Mendenhall	123.8	199.2		MS 149 north
			124.1	199.7		MS 540
			126.1– 126.4	202.9– 203.4		MS 13 – Mendenhall, Prentiss, Puckett	Interchange
		​	134.2	216.0		MS 149 south
	Rankin	Florence	145.5	234.2		MS 469 – Downtown Florence, Brandon
		Richland	151.8	244.3		Old Highway 49	Proposed MS 149 north; northbound exit and southbound entrance
			152.6– 152.9	245.6– 246.1		East Frontage Road	Interchange; northbound exit and entrance
						West Frontage Road	Interchange; southbound exit and entrance
		Richland–Pearl line	153.8	247.5	47	I-20 east / I-55 north to US 80 – Meridian, Grenada, Flowood	Southern end of I-20/I-55 concurrency; exit 94 on I-55
	Hinds	Jackson	154.3	248.3	45B	US 51 north	Southbound exit is exit 45
			154.6	248.8	45A	Gallatin Street	Southbound exit is exit 45
			155.3	249.9	44	I-55 south to US 51 south – McComb, New Orleans	Northern end of I-55 concurrency
			155.6	250.4	43	Terry Road / University Boulevard	Signed as exits 43A (south) and 43B (north)
			156.4	251.7	42	Ellis Avenue	Signed as exits 42A (south) and 42B (north)
			159.7	257.0	41	I-20 west – Vicksburg I-220 begins	Northern end of I-20 concurrency; southern terminus of I-220
			160	260	1	US 80 / MS 18 – Clinton, Pearl	Signed as exits 1A (east) and 1B (west)
			161.3	259.6	2	Clinton Boulevard / Capitol Street	Signed as exits 2A (Capitol Street) and 2B (Clinton Blvd.) northbound
			162.7	261.8	3	Industrial Drive	Diamond interchange
			164.7	265.1	5	I-220 north / Medgar Evers Boulevard	Signed as exits 5A (Medgar Evers) and 5B (I-220); northern end of I-220 concurrency
			167.1– 167.3	268.9– 269.2		Natchez Trace Parkway	Interchange
	Madison	Flora	179.0	288.1		MS 22 – Edwards, Flora, Canton, Mississippi Petrified Forest National Natural Landmark
	Yazoo	Bentonia	186.3	299.8		MS 830 west – Bentonia	Eastern terminus of MS 830
			187.0	300.9		MS 433 – Satartia, Bentonia
			187.7	302.1		MS 830 east – Bentonia	Western terminus of MS 830
		​	200.7	323.0		MS 16 east – Benton, Canton	Southern end of MS 16 concurrency
		Yazoo City	201.0	323.5		MS 16 west / MS 149 north – Downtown Yazoo City	Northern end of MS 16 concurrency
			204.2	328.6		US 49E north (Jerry Clower Boulevard) / US 49W north (Haley Barbour Parkway) to MS 3 south – Greenwood, Indianola, Vicksburg	Interchange; US 49 north splits into US 49E and US 49W
	See US 49E and US 49W
	Tallahatchie	Tutwiler	0.0	0.0		US 49W south (MS 3 south) / US 49E south – Indianola, Greenwood	Southern end of MS 3 concurrency; US 49 south splits into US 49E and US 49W
			0.4	0.64		MS 3 north – Marks, Lambert	Northern end of MS 3 concurrency
			0.6	0.97		MS 726 west
	Coahoma	Clarksdale	12.5	20.1		MS 322 east	Southern end of MS 322 concurrency
			13.0	20.9		US 61 south / US 278 west / MS 322 west – Clarksdale, Cleveland, Greenville, Delta Blues Museum	Interchange; northern end of MS 322 concurrency; southern end of US 61/US 278 concurrency
			116.3– 117.0	187.2– 188.3		US 278 east / MS 6 – Clarksdale, Batesville	Northern end of US 278 concurrency
​		118.0	189.9	MS 161 south – Lyon, North Clarksdale
​		27.3	43.9	Friars Point-Highway 61 / Highway 61-Jonestown – Friars Point, Moon Lake		Proposed MS 316
​		31.8	51.2	US 61 north / MS 315 south (Lula-Rich) / Great River Road – Tunica, Memphis, Sledge, Sardis		North end of US 61 overlap; south end of Great River Road overlap
​		37.9	61.0	MS 1 south – Friars Point, North Delta Museum
Mississippi River			40.9 0.00	65.8 0.00	Helena Bridge
Arkansas	Phillips	Helena-West Helena	0.99	1.59		US 49B north (Biscoe Drive) – Business District
			1.35	2.17		AR 20 to AR 44 – Lakeview, Elaine, Harbor and Industrial Park	Former AR 49
			3.98	6.41		AR 242 to AR 185
			6.28	10.11		US 49B south (North Sebastian Street) – Business District
			6.88	11.07		AR 185 north – Municipal Airport
		Walnut Corner	12.48	20.08		AR 1 north / AR 85 south – Barton, Lake View
		Kindall	15.45	24.86		AR 316 north – Rondo
		Poplar Grove	17.58	28.29		AR 316 south – Trenton
		Marvell	20.62	33.18		AR 243 north
			21.52	34.63		AR 1 south – DeWitt
		​	27.56	44.35		AR 39 south – Postelle, Turner
		​	29.67	47.75		AR 86 west – Holly Grove
	Monroe	​	33.56	54.01		AR 362 east – Louisiana Purchase Historic State Park
		​	35.60	57.29		AR 39 north – Blackton
		​	36.70	59.06		AR 366
		​	38.67	62.23		US 79 – Clarendon, Marianna, Stuttgart, Holly Grove
		​	41.30	66.47		AR 39S east – Monroe
		​	43.55	70.09		AR 39 south / AR 241 north – Rich
		​	50.67	81.55		AR 238S west
		Brinkley	51.80	83.36		US 70 west – DeValls Bluff	South end of US 70 overlap
			52.55	84.57		AR 238 east (West Sycamore Street)
			53.39	85.92		US 70 east (West Cypress Street)	Northern end of US 70 concurrency
			54.97	88.47		I-40 / US 63 south – Little Rock, Memphis	Southern end of US 63 concurrency; exit 216 on I-40
			56.13	90.33		AR 17 north – Cotton Plant
	Woodruff	​	62.47	100.54		AR 38 west – Cotton Plant
		Hunter	66.28	106.67		AR 306 east to AR 78
		​	71.61	115.25		AR 269 north to AR 145
		Penrose	76.23	122.68		AR 284 east to AR 193
	Cross	Fair Oaks	80.26	129.17		US 64 west – Bald Knob	Southern end of US 64 concurrency
			80.28	129.20		US 64 east – Wynne	Northern end of US 64 concurrency
		Tilton	84.88	136.60		AR 364 east – Vanndale
		Hickory Ridge	90.44	145.55		AR 42 to AR 37 – Cherry Valley
	Poinsett	Fisher	96.67	155.58		AR 214 east – White Hall
		Waldenburg	102.74	165.34		AR 14 – Newport, Harrisburg
		​	104.9	168.8		AR 956-1 – Lake Hogue Public Fishing
		​	109.34	175.97		AR 214 west – Grubbs
	Poinsett–Craighead county line	​	113.42	182.53		AR 158
	Craighead	Jonesboro	120.50	193.93		AR 226 west / US 78 west to US 67	Southern end of US 78/AR 226 concurrency
			122.4	197.0		AR 226 east (Woodsprings Road)	Northern end of AR 226 concurrency
			125.53	202.02	45	I-555 north / US 63 north / AR 18 west (Southwest Drive) – Walnut Ridge, Hoxie	Northern end of US 63 concurrency; southern end of I-555 concurrency
			43.4	69.8	44	AR 1B (Harrisburg Road)
			128.40	206.64	42	I-555 south / AR 1 south (Stadium Boulevard) / US 78 east / Caraway Road – Memphis, Harrisburg, Blytheville	Northern end of I-555/US 78 concurrency; southern end of AR 1 concurrency
			129.53	208.46		AR 18 (East Highland Drive)
			131.74	212.01		AR 91 north (East Johnson Avenue) to AR 141 – Jonesboro Business District	Southern terminus of AR 91
			132.31	212.93		AR 351 north (Old Greensboro Road)	Southern end of AR 351 concurrency
			132.75	213.64		AR 351 – Airport	Northern end of AR 351 concurrency
		​	136.7	220.0		US 49B north – Brookland Business District
		​	140.60	226.27		US 49B south – Brookland Business District
	Greene	Paragould	144.65	232.79		AR 69 north
			146.85	236.33		US 412
			147.34	237.12		AR 358 east
			147.87	237.97		AR 358 west
			149.71	240.93		US 412B / US 49B north – Walnut Ridge, Cardwell MO, Paragould Business District, Airport
			149.97	241.35		US 49Y to US 412B west – Walnut Ridge
			151.13	243.22		AR 135 – Corning, Business District
			151.88	244.43		US 49B south
		Marmaduke	161.44	259.81		AR 34 – Business District
	Clay	Rector	168.86	271.75		AR 90 west – Rector Business District	Southern end of AR 90 concurrency
			169.37	272.57		AR 119 south
		Hargrave Corner	172.33	277.34		AR 90 east – Kennett, MO	Northern end of AR 90 concurrency
		Piggott	182.33	293.43		US 62 / AR 1 north	Northern terminus; northern end of AR 1 concurrency
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access       Route transition

U.S. Highway 49E
Location	Yazoo City-Tutwiler
Length	85.862 mi (138.181 km)

U.S. Route 49E (US 49E) is an 85.86-mile-long (138.18 km) U.S. Highway in the Delta region of Mississippi. It travels through Yazoo, Holmes, Leflore, and Tallahatchie counties.

U.S. Highway 49W
Location	Yazoo City-Tutwiler
Length	81.894 mi (131.796 km)

U.S. Route 49W (US 49W) is an 81.89-mile-long (131.79 km) U.S. Highway in the Delta Region of Mississippi, passing through Yazoo, Humphreys, Sunflower, and Tallahatchie counties.

• U.S. Roads portal

• Arkansas Highway 349
• Mississippi Highway 149

• U.S. Route 49 Business in Brookland, Arkansas
• U.S. Route 49 Business in Helena-West Helena, Arkansas
• U.S. Route 49 Business in Jonesboro, Arkansas (decommissioned)
• U.S. Route 49 Business in Paragould, Arkansas
• U.S. Route 49E Business in Greenwood, Mississippi (decommissioned)
• U.S. Route 49 Business in Hattiesburg, Mississippi (decommissioned)

• Endpoints of U.S. Highway 49

Browse numbered routes
← AR 48	AR	→ AR 50
← MS 48	MS	→ MS 50