U.S. Highway 75 (US 75) is a part of the U.S. Highway System that travels from Interstate 345 (I-345) in Dallas, Texas northward to the Canadian border in Noyes, Minnesota. In the state of Texas it runs from I-345 in Dallas and heads north to the Oklahoma state line, a distance of about 75.3 miles (121.2 km).

In the initial assignment of state highways in 1917, Dallas-Fort Worth and Houston were connected by a branch of State Highway 2 (SH 2, the Meridian Highway), which ran via Waco and Bryan and continued on to Galveston. The more direct route followed by US 75 was not initially part of the system between Richland (connected to Dallas by SH 14) and Huntsville (connected to Houston by SH 19). This Richland–Huntsville cutoff was added by 1919 as SH 32, and US 75 was assigned to the alignment, as well as SH 6 north of Dallas, in 1926. The branch of SH 2, which US 75 followed between Houston and Galveston, eventually became part of SH 6, and these numbers were dropped in the 1939 renumbering.

Prior to the coming of the Interstate Highway System in the late 1950s, the only improvements to US 75 in Texas beyond building a two-lane paved roadway were in the Houston and Dallas areas. However, the highways in and near these cities included some of the first freeways in the state: the Gulf Freeway (Houston, opened to traffic on October 1, 1948) and the Central Expressway. When I-45 was built in the 1960s, its alignment bypassed many of the towns and built-up areas between Downtown Dallas and Houston. The bypassed routes retained the US 75 designation until the designation was truncated to Downtown Dallas in 1987. Many of the original alignments continue to exist under other designations.

In Dallas, the route followed what is now the Good Latimer Expressway (formerly Spur 559) southeast, out of downtown, along US 175 and south along SH 310.

Near Ferris, Trumbull, Palmer, Ennis, and Corsicana Interstate 45 veers east to avoid the more populated areas. The old US 75 alignments through these towns, decommissioned in 1987, now carry the following designations:

• I-45 Business-J (originally Loop 560) through Ferris
• Loop 561 through Trumbull
• I-45 Business-H through Palmer (originally Loop 562)
• Spur 469, I-45 Business-G (originally US 287 and Spur 563) through Ennis
• Interstate 45 Business-F (originally Loop 564) through Corsicana

Through Streetman, Fairfield, Buffalo, Centerville, Madisonville, Huntsville, New Waverly, Willis, and Conroe, US 75 followed what is now SH 75.

In Galveston, the alignment of State Highway 87 from 20th Street to the southern terminus I-45 was also part of US 75 until its 1987 truncation.

In other cases alignments were bypassed while US 75 remained in existence; they now carry the following designations:

• SH 3 through La Marque, Dickinson, League City, South Houston and Houston, bypassed 1952
• SH 5 from north of Dallas via Plano, McKinney, Anna and Van Alstyne to Howe, bypassed 1959-1967
• SH 91 from Sherman to Denison, bypassed 1984

US 75 begins at I-345, an unsigned auxiliary route of I-45 and heads north, first interchanging Spur 366 northeast of Dallas. The highway then interchanges with SL 12 (Northwest Highway) before forming the High Five Interchange with I-635. Then, it interchanges with the President George Bush Turnpike as it continues north through Plano. It then interchanges with the Sam Rayburn Tollway, becoming concurrent with SH 121 and then heads through McKinney and interchanging with US 380. The stretch through McKinney is largely unchanged from its original design except for its intersection at the Sam Rayburn Tollway. to replace the original interchange. Plans to upgrade the facility through and north of McKinney are under way with the reconstruction of the US 380 bridge. US 75 then splits from SH 121 in Melissa and continues north. In Sherman, the route crosses over SH 56 and then US 82. North of Denison, it becomes concurrent with US 69 for the next 2 miles (3.2 km) before crossing over the Red River and into Oklahoma.

The exit numbers for US 75 are not based on mile markers; instead, the exits were numbered consecutively (the only remaining stretch of road in Texas with such a system). As the bypass route was completed around the Sherman–Denison area, the numbering system was continued for the new exits. Upon completion of the widened Central Expressway through Dallas, the exit numbering was changed for the section south of I-635 to correspond with the new (and fewer number of) exits, based on mileage, but the numbering system north of I-635 was left unchanged, thus explaining the gap in the current numbering system.

County	Location	mi	km	Old exit	New exit	Destinations	Notes
Dallas	Dallas	0.0	0.0			To I-45 south – Houston	Southern terminus; access via I-345
					286A (NB) 1A (SB)	To I-35E – Waco, Denton	Access via Spur 366 (Woodall Rodgers Freeway)
		0.2	0.32	1–2	1A	Hall Street, Lemmon Avenue	Northbound exit and entrance
		0.7	1.1	2–4	1B	Haskell Avenue/Blackburn Street, Lemmon Avenue, Fitzhugh Avenue
		1.6	2.6	4–6	2	Knox Street/Henderson Avenue, Fitzhugh Avenue, Monticello Avenue
		3.0	4.8	6–10	3	Mockingbird Lane, Monticello Avenue, SMU Boulevard	Access to SMU/Mockingbird station
		4.1	6.6	10–12	4A	Lovers Lane, SMU Boulevard, Southwestern Boulevard
		4.8	7.7	13	4B	Caruth Haven Lane	No direct southbound exit (signed at exit 5A)
		5.0	8.0	14–15	5A	Loop 12 (Northwest Highway)
		5.2	8.4	16	5B	NorthPark Boulevard, Park Lane	Access to Park Lane station
		6.1	9.8	17–18	6	Walnut Hill Lane, Meadow Road	Access to Walnut Hill station, Presbyterian Hospital of Dallas, and Walnut Hill Medical Center
		7.3	11.7	18–19	7	Royal Lane, Meadow Road
		8.1	13.0	20A	8A	Forest Lane	No direct southbound exit (signed at exit 20); access to Forest Lane station, Forest Park Medical Center–Dallas, and Medical City Dallas Hospital
		8.3	13.4	20B	8B	Coit Road	Northbound exit and southbound entrance
		8.7	14.0		20	Churchill Way	Signed as exit 20B northbound
		9.0	14.5		21	I-635	High Five Interchange; exit 19A on I-635
						I-635 Express west	Tolled; southern terminus of managed HOV lanes; southbound exit and northbound entrance
					♦	US 75 south / I-635	Managed HOV lanes access only; southbound exit and northbound entrance
		10.4	16.7		22A	Frontage Road	Southbound exit and northbound entrance
		9.6	15.4		22	Midpark Road
	Richardson	10.5	16.9		23	Spring Valley Road	Access to Spring Valley station
		11.2	18.0		24	Belt Line Road/Main Street
		12.1	19.5		25	Arapaho Road, Collins Boulevard	Access to Arapaho Center station
		12.9	20.8		26	Campbell Road, Collins Boulevard, Galatyn Parkway
Collin		14.1	22.7		27	Renner Road, Galatyn Parkway	Signed as exit 27A northbound; access to Galatyn Park station
	Richardson–Plano line	15.4	24.8		28A	Plano Parkway, 15th Street	Access to CityLine/Bush station; 15th Street is former FM 544
		15.7	25.3		28B	Pres. George Bush Turnpike	Northbound entrance includes direct exit ramp onto 15th Street (exit 29)
	Plano	16.5	26.6		29	Park Boulevard, 15th Street	No northbound exit; access to Medical Center of Plano; 15th Street is former FM 544
		17.6	28.3		30	Parker Road	Access to Parker Road station
		18.8	30.3		31	Spring Creek Parkway	Southbound access via exit 32
		20.1	32.3		32	Legacy Drive
	Allen				♦	Managed HOV lanes	Northern terminus of Managed HOV lanes; southbound exit and northbound entrance
		21.5	34.6		32A	Frontage Road	Southbound exit only
		22.1	35.6		33	Bethany Drive
		22.5	36.2		34	McDermott Drive	Former FM 2170
		23.6	38.0		35	Allen Drive	Southbound access via exit 36
		23.9	38.5		36	Exchange Parkway	Access to Texas Health Presbyterian Hospital Allen
	Fairview–Allen line	24.4	39.3		37	Stacy Road	Former FM 2786 east; FM 2786 is still signed on the exit sign
		26.5	42.6		38A	Ridgeview Drive
		26.6	42.8		38B	Frontage Road	Northbound exit only; access to Medical Center of McKinney
	Fairview–Allen– McKinney city tripoint	26.8	43.1		38C	Sam Rayburn Tollway south To SH 5	No direct access from US 75 south to Spur 399/SH 5
		27.6	44.4		39A	SH 121 south / Eldorado Parkway – Airport	Southern end of the concurrency with SH 121; access to Medical Center of McKinney
	McKinney	28.7	46.2		39B	Frontage Road	Southbound exit only
		28.9	46.5		40A	Louisiana Street/Virginia Parkway	Former FM 3038 west; former Spur 359 east
		30.4	48.9		40B	White Avenue	No direct southbound exit
		31.2	50.2		41	US 380 – Greenville, Denton	Access to Baylor Scott & White Medical Center McKinney
		31.7	51.0		42	Wilmeth Road	Signed as exit 42A northbound and exit 42B southbound
		32.7	52.6		42	Bloomdale Road	Signed as exit 42B northbound and exit 42A southbound
		33.4	53.8		43	FM 543 / Laud Howell Parkway
	Melissa	35.4	57.0	45	44-45	SH 121 north – Bonham	Northern end of the concurrency with SH 121; northbound exit and southbound entrance; exit 44 northbound and exit 45 southbound
		35.7	57.5	44	45	SH 121 north / Bucees Boulevard – Bonham	Bucees Boulevard not signed southbound; SH 121 access southbound only
		36.3	58.4		46	Melissa Road
		38.4	61.8		47A	Throckmorton Road
	Anna	39.0	62.8		47B	Collin County Outer Loop
		40.9	65.8		48A	FM 455 (White Street)
		41.5	66.8		48B	Rosamond Parkway
		43.8	70.5		49	Mantua Road
Collin–Grayson county line	Van Alstyne	45.0	72.4		50	County Line Road
Grayson		46.2	74.4		51	FM 121 (Van Alstyne Parkway)	Due to confusion between this road and SH 121 to the south, southbound signs are marked "DFW Traffic Use Exit 38C"
	Van Alstyne–Howe city line	49.7	80.0		52	Blythe Road/West Farmington Road
	Howe	51.9	83.5		53	Spur 381 (Haning Street)
		54.3	87.4		54	SH 5 south / FM 902
	Sherman	55.8	89.8		54A	Shepherd Drive
		57.4	92.4		55	Frontage Road
		59.1	95.1		56	FM 1417
		59.6	95.9		56A	South Travis Street	Former northbound exit and southbound entrance
		59.9	96.4		56B	Frontage Road	Former northbound exit only
		60.5	97.4		57	Park Street, Center Street
		61.9	99.6		58	SH 56 (Lamar Street, Houston Street)
		62.3	100.3		59	Washington Street
		62.9	101.2		60	FM 131 north (North Travis Street) / Taylor Street
		63.2	101.7		61	SH 91 north (Texoma Parkway)	No southbound exit
		63.9	102.8		62	Lamberth Road, Taylor Street	No northbound entrance
		64.3	103.5		63	US 82 – Bonham, Gainesville	Exit 642 on US 82
		64.8	104.3		64	South Loy Lake Road, Fallon Drive
	Sherman–Denison city line	67.2	108.1		65	FM 691 – Grayson College, Airport	Access to Texoma Medical Center
	Denison	68.3	109.9		66	Spur 503 east – Denison	Spur 503 exit 596 to US 75 northbound
		68.8	110.7		67	North Loy Lake Road
		70.1	112.8		68	Crawford Street
		71.0	114.3		69	FM 120 (Morton Street)
		72.2	116.2		70	FM 84
		73.3	118.0		71	Randell Lake Road
		74.3	119.6		72	SH 91
		75.3	121.2		73	US 69 south – Denison, Greenville	Southern end of the concurrency with US 69
		76.1	122.5		74	Frontage Road	Southbound exit and entrance
		77.2	124.2		75	Texas Travel Info Center	Southern end of the concurrency with northbound US 69; signed as exit 74 northbound
		77.4	124.6			US 69 north / US 75 north – Durant	Continuation into Oklahoma
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Electronic toll collection       Closed/former       HOV only       Incomplete access

• U.S. Roads portal

• US 75 info page - at dfwfreeways.info

U.S. Route 75
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