U.S. Highway 285 (US 285) travels from Sanderson, Texas to Denver, Colorado. In Texas, US 285 begins at an intersection with US 90 in Sanderson, traveling through Fort Stockton and Pecos before exiting the state into New Mexico between Pecos and Carlsbad.

US 285 begins at an intersection with U.S. Route 90 in Sanderson, just west of the downtown area. The highway travels through highly rural areas of Terrell and Pecos County before entering Fort Stockton. In Fort Stockton, US 285 shares a short overlap with U.S. Route 385 and meets Interstate 10 before leaving the town. US 285 has an interchange with Farm to Market Road 1776, which serves the Firestone Tire and Rubber Company test track. After FM 1776, US 285 takes on a highly rural route until entering Pecos, where the highway meets with Interstate 20. US 285 briefly runs through Culberson County before crossing the state line into New Mexico.

US 285 has acquired the nickname "Death Highway" because the traffic from oil tank trucks has increased the number of road fatalities by 67% since the beginning of the 2010s oil boom.

County	Location	mi	km	Destinations	Notes
Terrell	Sanderson			US 90 – Alpine, Del Rio
Pecos	​			RM 2400 east – Sheffield
	Fort Stockton			US 385 north / I-10 BL east – McCamey	South end of US 385/BL I-10 overlap
				FM 1053 north
				US 385 south – Marathon	North end of US 385 overlap
				SH 18 north – Monahans
				I-10 BL west – Van Horn	North end of BL I-10 overlap
				I-10 / US 67 – El Paso, Bakersfield	I-10 exit 257
	​			FM 1776 – Coyanosa	Interchange
Reeves	​			FM 2007 south
	​			FM 1450 east
	Pecos			I-20 – El Paso, Odessa	I-20 exit 42
				I-20 BL – Toyah, Barstow	Former US 80
	​			FM 1216 north
	​			SH 302 east – Mentone, Kermit
	Orla			RM 652
Culberson	​			US 285 north – Carlsbad	Texas–New Mexico state line
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus