U.S. Highway 350 (US 350) is a 73-mile-long (117 km) northeast–southwest United States highway located entirely within the state of Colorado.

US 350 starts at a junction with US 160 northeast of Trinidad. The highway runs northeast, past the Perry Stokes Airport and crossing the Purgatoire River. It then continues the rest of its length along a route chosen by the Atchison, Topeka and Santa Fe Railway, and close to the Mountain Branch of the Santa Fe Trail. The highway passes just northeast of the Piñon Canyon Maneuver Site, then crosses Comanche National Grassland before a junction with SH 71 going north. At La Junta, the highway turns east on 5th Street, then north on Barnes Avenue before ending at a junction with US 50.

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Until the 1990s, US 350 continued into Trinidad, where it intersected with Interstate 25 (I-25). Prior to the creation of I-25, the road terminated at US 85 and US 87.

County	Location	mi	km	Destinations	Notes
Las Animas	​	0.000	0.000	US 160 / Santa Fe Trail Scenic Byway – Trinidad, Springfield	Western terminus
Otero	​	59.412	95.614	SH 71 north – Rocky Ford	Southern terminus of SH 71
	La Junta	72.464	116.620	US 50 / Santa Fe Trail Scenic Byway – Pueblo, Lamar	Eastern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• U.S. Route 50

• Endpoints of US highway 350
• Media related to U.S. Route 350 at Wikimedia Commons