U.S. Route 412 (US 412) enters the state of Missouri from Arkansas near Cardwell. The highway leaves the state into Tennessee concurrent with I-155 near Caruthersville.

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US 412 enters the state from Arkansas after crossing the St. Francis River. The highway enters into the small town of Cardwell before turning to the north. In Kennett, the highway turns back to the east, concurrent with Route 84. In Hayti, US 412 has an interchange with I-55 and travels concurrent with I-155. The two highways cross the Mississippi River on the Caruthersville Bridge into Tennessee.

County	Location	mi	km	Exit	Destinations	Notes
St. Francis River		0.00	0.00		US 412 west – Paragould	Continuation into Arkansas
					Arkansas–Missouri state line
Dunklin	Cardwell	2.922	4.703		Route 164 east / Route F – Cardwell, Monette
	​	4.427	7.125		Route 164 – Cardwell, Steele
	​	7.065	11.370		Route 108 south – Arbyrd
	Kennett	23.598	37.977		Route 84 west – Rector	West end of Route 84 overlap
		23.810	38.318		Route 25 north – Holcomb
Pemiscot	Hayti	37.884	60.968		Route 84 east – Hayti	East end of Route 84 overlap
		40.044– 40.677	64.445– 65.463	1	I-55 / US 61 / I-155 begins – St. Louis, Chicago, Memphis	West end of I-155 overlap; signed as exits 1A (south) & 1B (north). I-55 exits 17A-B.
	​	46.813	75.338	6	Route 84 west / Route Y south – Caruthersville
Mississippi River		50.767	81.702	Caruthersville Bridge; Missouri–Tennessee state line
					I-155 east / US 412 east – Dyersburg	Continuation into Tennessee
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

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U.S. Route 412
Previous state: Arkansas	Missouri	Next state: Tennessee