U.S. Route 441 (US 441) stretches for 83.28 miles (134.03 km) through the mountains of East Tennessee, connecting Rocky Top with Knoxville, Sevierville, Gatlinburg, and the Great Smoky Mountains National Park, crossing into North Carolina at Newfound Gap. Near its northern terminus, US 441 crosses over Norris Dam and passes through Norris Dam State Park.

SR 71 begins concurrent with US 441 within the Great Smoky Mountains National Park at the North Carolina state line on Newfound Gap. US 441/SR 71 is known as Newfound Gap Road within the park, and follows along a valley carved by the West Prong of the Little Pigeon River as a narrow and curvy two-lane highway. Newfound Gap Road then runs concurrently with SR 73 Scenic (Little River Road) before having an interchange with the Gatlinburg Bypass and entering the city of Gatlinburg, where US 441/SR 71/SR 73 Scenic leaves the park and becomes Great Smoky Mountains Parkway (Parkway), a four-lane undivided highway as it passes through the city. Parkway then has an intersection with US 321/SR 73 (East Parkway), where SR 73 Scenic ends and US 321/SR 73 joins Parkway. Parkway heads north to have another interchange with the Gatlinburg Bypass before leaving Garlinburg and becoming a divided highway known as the Foothills Parkway Spur (more commonly known as The Spur). Parkway then enters the city of Pigeon Forge and widens to a six-lane. It passes through the city and has an intersection with SR 449 (Dollywood Lane/Veterans Boulevard) before US 321/SR 73 head north along Wears Valley Road. US 441/SR 71 (Parkway) then crosses a bridge over the West Prong of the Little Pigeon River to enter Sevierville. They pass by several tourist attractions and a Tanger Outlets before again crossing the West Prong of the Little Pigeon River and turning of the Parkway and north onto Forks of the River Parkway at the southern edge of downtown. They bypass downtown on the west side as an undivided highway before coming to an intersection with SR 66 (Winfield Dunn Parkway) and US 411/SR 35 (W Main Street), where US 441/SR 71 turns left to become concurrent with US 411/SR 35 as a four-lane undivided highway known as Chapman Highway. Chapman Highway then crosses a bridge over West Prong of the Little Pigeon River and leaves Sevierville as a divided highway through rural areas. It then passes through some mountainous areas as an undivided highway before entering Seymour. Chapman Highway passes by several homes and businesses before coming to an intersection with SR 338 (Boyds Creek Highway), where US 411/SR 35 heads south along Maryville Highway. US 441/SR 71 (Chapman Highway) continues north to pass through a small portion of Blount County before leaving Seymour and crossing into Knox County.

US 441/SR 71 (Chapman Highway) passes through suburban areas as it enters South Knoxville. It has an interchange with SR 168 (Governor John Sevier Highway) before passing through a business district. SR 71 then breaks off along E Moody Avenue just before becoming concurrent with SR 33 (Martin Mill Pike) and crossing the Tennessee River into downtown Knoxville via the Henley Street Bridge. US 441/SR 33 passes through downtown as a six-lane divided highway (known as Henley Street), where it has a partial interchange with I-40/I-275 and an intersection with SR 62 (Western Avenue). The highway narrows to a two-lane undivided to cross a bridge over some railroad tracks before passing under I-40 and passing through neighborhoods as Broadway. US 441/SR 33 then have a partial interchange with Hall of Fame Drive (unsigned SR 71), with SR 71 rejoining US 441/SR 33, where the roadway widens to four-lanes. Broadway then crosses Sharp's Ridge to enter Fountain City, where it has an intersection with SR 331 (Old Broadway) and an interchange with I-640/US 25W/SR 9 (Exit 6). Broadway has a partial interchange with SR 331 (Tazewell Pike) before it passes through a business district before passing through downtown. It then becomes a divided highway as it crosses a ridge, where it leaves Fountain City and Knoxville to enter Halls Crossroads. Broadway now becomes Maynardville Pike and passes through suburban areas and business districts before US 441/SR 71 splits off from SR 33 (Maynardville Pike) along Norris Freeway as a four-lane undivided highway shortly before having an intersection with SR 131 (E Emory Road). The highway then narrows to two-lanes and leaves Halls Crossroads to pass through rural areas. It then becomes concurrent with SR 170 (Old Raccoon Valley Road) before crossing into Anderson County.

SR 170 splits off from US 441/SR 71 (Norris Freeway) along Hickory Valley Road before US 441/SR 71 continues north through rural areas to enter the city of Norris, where they have a short concurrency with SR 61 (Andersonville Highway/Charles G. Seviers Boulevard) before passing through Norris Dam State Park and crossing the Clinch River on top of the Norris Dam. The highway turns east and becomes windy and curvy as its crosses into Campbell County twice for short distances before re entering Anderson County to enter Rocky Top. US 441/SR 71 then have an interchange with I-75 (Exit 128) and widen to an undivided four-lane shortly before coming to an end at an intersection with US 25W/SR 9/SR 116 (N Main Street) just north of downtown.

County	Location	mi	km	Destinations	Notes
Sevier	Great Smoky Mountains National Park	0.0	0.0	US 441 south (Newfound Gap Road) – Cherokee	Continuation into North Carolina
				SR 73 Scenic west (Little River Road/SR 337 west) – Townsend, Elkmont, Cades Cove	Southern end of SR 73 Scenic concurrency
				Gatlinburg Bypass north – Pigeon Forge	Southern terminus of Gatlinburg Bypass
	Gatlinburg			US 321 north (East Parkway/SR 73 east) – Pittman Center, Cosby, Newport	Southern end of wrong-way concurrency with US 321/SR 73; eastern terminus of SR 73 Scenic
				Gatlinburg Bypass south – Cherokee	Interchange; no northbound access
	Pigeon Forge			SR 449 north (Dollywood Lane/Veterans Parkway) – Dollywood	Southern terminus of SR 449
				US 321 south (Wears Valley Road/SR 73 west) – Wears Valley, Townsend	Northern end of wrong-way concurrency with US 321/SR 73
	Sevierville			Parkway to SR 66 (Winfield Dunn Parkway) / SR 448 (North Parkway)
				US 411 north (West Main Street/SR 35 north) / SR 66 / I-40 north (Winfield Dunn Parkway) – Newport, Kodak	Southern end of wrong-way concurrency with US 411/SR 35; southern terminus of SR 66
	Seymour			US 411 south (Maryville Highway/SR 35 south) – Maryville, Alcoa SR 338 north (Boyds Creek Highway) – Boyds Creek	Northern end of wrong-way concurrency with US 411/SR 35; southern terminus of SR 338
Knox	South Knoxville			SR 168 (Governor John Sevier Highway) – Johnson University, Strawberry Plains	Interchange
				E Moody Avenue (SR 71 north) to South Knox Boulevard	Northern end of SR 71 concurrency
				SR 33 south (Martin Mill Pike) – Rockford	Southern end of SR 33 concurrency
	Knoxville			Henley Street Bridge over the Tennessee River
				Main Street (east)/Cumberland Avenue (west) - University of Tennessee, West Knoxville	Former southern end of US 11/US 70/SR 1 concurrency
				I-40 / I-275 – Nashville, Asheville, NC, Lexington, KY	I-40 exit 388; I-275 exit 0A
				SR 62 west (Western Avenue) – Karns, Oak Ridge	Eastern terminus of SR 62
				West Fifth Avenue – Asheville, NC	Former northern end of US 11/US 70/SR 1 concurrency; SR 33 turns primary
				Hall of Fame Drive (unsigned SR 71 south)	Southbound exit and northbound entrance; southern end of SR 71 concurrency: to US 11/US 70/SR 1 and Women's Basketball Hall of Fame
	Fountain City			SR 331 north (Old Broadway) – Corryton	Southern terminus of SR 331
				I-640 / US 25W (SR 9) – Nashville, Asheville	I-640/US 25W exit 6
				SR 331 north (Old Broadway) – Corryton	Interchange; northbound exit and southbound entrance
	Halls Crossroads			SR 33 north (Maynardville Pike) – Maynardville	Northern end of SR 33 concurrency
				SR 131 (E Emory Road) – Powell, Gibbs
	​			SR 170 west (Old Raccoon Valley Road) – Heiskell, Claxton	Southern end of SR 170 concurrency
Anderson	​			SR 170 east (Hickory Valley Road) – New Tazewell	Northern end of SR 170 concurrency
	Norris			SR 61 (Andersonville Highway) – Andersonville, Big Ridge State Park	Southern end of SR 61 concurrency
				SR 61 west (North Charles G. Seivers Boulevard) – Clinton	Northern end of SR 61 concurrency
Clinch River				Norris Dam
Campbell	No major junctions
Anderson	No major junctions
Campbell	No major junctions
Anderson	Rocky Top			I-75 – Knoxville, Lexington	I-75 exit 128
		85.8	138.1	US 25W / SR 116 (North Main Street/SR 9) – Caryville, downtown, Briceville, Clinton	Northern terminus of US 441 and SR 71
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

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