U.S. Route 380 (US 380) is an east–west United States highway. The highway's eastern terminus is in Greenville, Texas at an intersection with Interstate 30, of which the easternmost 3–4 miles are concurrent with US 69 in a loop around the west and south sides of Greenville. Its western terminus is at San Antonio, New Mexico, south of Socorro at an intersection with Interstate 25. It intersected with its parent, U.S. Route 80, at Cisco until 1971, when it was rerouted along the former SH 24 from that highway's western terminus near Old Glory to Greenville. Former U.S. Route 380 from Cisco to near Old Glory became an extension of SH 6. The highway no longer connects to any x80 route. US 380 passes through some of the far northern suburbs of the Dallas/Fort Worth Metroplex, including (from west to east) Denton, Frisco, McKinney and Princeton. The portion in Texas from the New Mexico state line to Jayton was SH 84 before 1939. Its spur, SH 84A, went from Jayton to Aspermont, until 1930, when it became SH 161.

US Route 380 begins at an intersection with Interstate 25 just west of San Antonio, New Mexico, and travels through town, meeting the old route of US 85, now New Mexico State Road 1. It then travels generally east, and marks the northern edge of the White Sands Missile Range. The road then turns southeast, crossing the Carrizozo Malpais before reaching Carrizozo, meeting U.S. Route 54. The route continues southeast, climbing the Sacramento Mountains, and going through the town of Capitan and briefly travelling through the Lincoln National Forest, before reaching U.S. Route 70 at Hondo and becoming concurrent with US 70.

These routes continue eastward, next reaching Roswell, New Mexico. US 380 splits with US 70 in Roswell, then crossing U.S. Route 285 in Roswell before continuing east across oil-producing areas of the Llano Estacado of east New Mexico and the Texas South Plains.

US 380 enters Texas at a crossing with Farm to Market Road 769, travelling generally due east before meeting up with US Route 82 in Plains. They continue east passing the former locations of Tokio and Gomez before reaching Brownfield. In Brownfield, it meets US Routes 62 and 385, and all 4 routes coincide for 3 blocks through the center of town before US 380 splits to the east.

The route continues due east through Texas South Plains farmland, passing through Tahoka, before falling off the Llano Estacado and reaching Post. The highway then meanders east through rural Garza and Kent Counties before reaching the ghost town of Clairemont. The route then travels east, where it meets Texas State Highway 70, which both then turn northeast until reaching Jayton, where US 380 takes a sharp turn back to the southeast. The road then travels through several thousand acres of private ranchland in Kent and Stonewall Counties before reaching Swenson.

The route continues to the southeast, reaching an intersection with US 83, where both continue southeast into the town of Aspermont. The route continues to the east and northeast through the communities of Old Glory, Rule, Haskell, Throckmorton, and Newcastle, before crossing Lake Graham and reaching the city of Graham.

US 380 continues to the east and northeast through Bryson before reaching an intersection with US Route 281 and Texas State Highway 114 in Jacksboro. US 281 departs southward out of town, while US 380 and TX 114 depart east south of Jacksboro, crossing Lake Bridgeport before reaching the city of Bridgeport. US 380 then travels due east toward the city of Decatur.

US 380 exits to the east and reaches an intersection with Interstate 35 on the west end of Denton where it is known as University Drive. US 380 continues through the city of Denton, intersecting US Route 77 and US 377 near Texas Woman's University, before continuing east with US 377. The routes cross the very northern edge of Lake Lewisville before US 377 departs off to the north. US 380 continues east through the town of Cross Roads and the city of Little Elm. Then US380 meets the northern terminus of the Dallas North Tollway in Frisco, before reaching McKinney, where it is also known as University Drive. The route then continues east, passing through Princeton before crossing the northern fringe of Lake Lavon, and reaching Farmersville, where it is signed as the Audie Murphy Parkway. The route again continues east, passing just south of Floyd, before reaching an intersection with US Route 69 on the far western edge of Greenville. Both of those routes then follow a loop around the south end of Greenville, before reaching the routes eastern terminus at an intersection with Interstate 30 and US Route 67.

The route has two special routes, both business routes in Texas.

This is the former route of US 380 through the city of Decatur. The route was bypassed in 1987, with the old route being renamed Texas State Highway Loop 569. The route was re-designated as the business route in 1991.

This is the former route of US 380 through the town of Floyd. The route was bypassed in 1968, when the route was still known as Texas State Highway 24, with the old routing being designated as Texas State Highway Loop 462. The route was re-designated as the business route in 1991.

U.S. Highway 566
Location	Ruidoso, New Mexico–Socorro, New Mexico
Existed	1926–1931

When US 380 was commissioned in 1931, it took over the entire former route of U.S. Route 566, an original 1926 route. The entire route of US 566 was within the state of New Mexico, from an intersection with (modern day New Mexico State Road 48) and (modern-day US 70) east of Ruidoso to US 85 (originally planned as US 466) in Socorro, New Mexico. US 566 never intersected with its nominal parent, U.S. Route 66 although it temporarily connected to that parent indirectly via U.S. Route 366.

The section of highway from the New Mexico state line to Jayton was previously SH 84. A spur route, SH 84A, went from Jayton to Aspermont, being changed to Texas State Highway 161 in 1930.
US 380 east of Denton, and west of McKinney, has had numerous fatal vehicle accidents, per public statements by law enforcement and fire department officials. This is believed to be attributed by the lack of a center median, high traffic volume, and excessive speeds.

State	County	Location	mi	km	Destinations	Notes
New Mexico	Socorro	​			I-25 (US 85) – Las Cruces, Socorro	Western terminus; I-25 exit 139
		San Antonio			NM 1 – Luis Lopez, El Camino Real IHC, Bosque del Apache National Wildlife Refuge, Fort Craig
		​			NM 525 south
	Lincoln	Carrizozo			US 54 – Vaughn, Tularosa
		​			NM 37 – Nogal, Ruidoso
		Capitan			NM 48 south (South Lincoln Avenue) / NM 246 (Pine Lodge Road) – Ruidoso
		​			NM 220 – Fort Stanton, Sierra Blanca Regional Airport, Fort Stanton Museum
		Hondo			US 70 west – Ruidoso	West end of US 70 overlap
		Tinnie			NM 368 – Arabela
	Chaves	Roswell			US 70 Truck east / US 285 Truck (Relief Route) – Roswell International Air Center
					US 70 east / US 285 (Main Street) – Vaughn, Artesia, NMMI	East end of US 70 overlap
		​			NM 254 – East Grand Plains
		​			NM 409 – Bottomless Lakes State Park
		​			NM 172 – Maljamar
	Lea	​			NM 457 south to US 82 – Artesia
		Tatum			NM 206 – Portales, Lovington
		​			NM 125 – Bledsoe
New Mexico–Texas line	Lea–Yoakum county line	​			FM 769
Texas	Yoakum	Plains			US 82 west – Lovington	West end of US 82 overlap
	See US 82
	Terry	Brownfield			US 62 east / US 82 east / US 385 north (North Lubbock Highway) – Lubbock	East end of US 62 / US 82 / US 385 overlap
		​			FM 168 north	West end of FM 168 overlap
		​			FM 168 south	East end of FM 168 overlap
	Lynn	West Point			FM 179 – Wolfforth, Lamesa
		​			FM 1328 north
		​			FM 3112 south
		Tahoka			Loop 472 (North Main Street)
					US 87	Interchange
		​			FM 2956 south
		​			FM 1054 north	West end of FM 1054 overlap
		​			FM 1054 south – Draw	East end of FM 1054 overlap
		​			FM 212
	Garza	​			FM 399 north	West end of FM 399 overlap
		​			FM 399 south	East end of FM 399 overlap
		Post			FM 669 south (Avenue M) – Gail
					US 84 east (Avenue J) – Snyder	West end of US 84 overlap
					US 84 west (Avenue J) – Lubbock	East end of US 84 overlap
					SH 207 north / Loop 46 south / FM 651 north (Avenue F)
		​			FM 2008 north
	Kent	​			FM 1081 north
		​			SH 208 south – Snyder	West end of SH 208 overlap
		Clairemont			SH 208 north – Spur	East end of SH 208 overlap
		​			SH 70 south – Rotan	West end of SH 70 overlap
		​			FM 1083 north
		​			SH 70 north – Jayton, Spur	East end of SH 70 overlap
	Stonewall	​			FM 2211 east – Peacock
		Swenson			FM 1416 north
		​			US 83 north – Guthrie	West end of US 83 overlap
		Aspermont			FM 1263 north (North Second Street)
					US 83 south / FM 610 west – Hamlin, Rotan	East end of US 83 overlap
					FM 3457 north
		​			SH 283 east – Stamford, Sagerton
		Old Glory			Loop 128 east – Old Glory
					FM 1835
					Loop 128 west – Old Glory
	Haskell	Rule			FM 617 east
					SH 6 – Rochester, Stamford
		​			FM 2407 west
		Haskell			Bus. US 277 – Weinert, Stamford
					US 277 – Weinert, Stamford	Interchange
					FM 600 south – Paint Creek
		​			FM 618 south – Paint Creek, Lake Stamford
		​			FM 266 north
	Throckmorton	​			SH 222 north – Munday
		​			FM 2651 north
		​			FM 923 south
		Throckmorton			US 183 / US 283 / SH 79 north – Seymour, Albany, Breckenridge
		​			FM 1711 north – Elbert
	Young	​			FM 578 north to SH 79	West end of FM 578 overlap
		​			FM 578 south – Breckenridge	East end of FM 578 overlap
		​			FM 61 east – Fort Belknap
		Newcastle			FM 926 west to SH 251 – Olney
		​			FM 1769 north – Jean
		Graham			SH 16 north	West end of SH 16 overlap
					SH 16 south (Elm Street) / SH 67 south	East end of SH 16 overlap
					FM 3491 north (Cliff Drive)
					FM 2179 south
		​			FM 2075 west
	Jack	Bryson			FM 3209 south
					FM 1191 south	West end of FM 1191 overlap
					FM 1191 north – Jermyn	East end of FM 1191 overlap
		​			FM 4 south – Graford
Jacksboro				US 281 north / SH 114 west (Main Street) / SH 59 north (Belknap Street)	West end of US 281 / SH 114 / SH 199 overlap
				PR 61 – Fort Richardson State Park
​				US 281 south / SH 199 east – Mineral Wells, Fort Worth	East end of US 281 / SH 199 overlap
​				FM 1156 north – Wizard Wells
Vineyard				FM 1156 – Wizard Wells, Joplin
Wise	Bridgeport			FM 1658 north
				FM 1658 – Bridgeport
				SH 114 east / SH 101 north – Rhome	East end of SH 114 overlap
				Loop 373 – Bridgeport
	​			FM 1655 north – Alvord, Weatherford College
	Decatur			Bus. US 380 east to FM 51 south – Decatur
				US 81 / US 287 – Wichita Falls, Fort Worth	Interchange
				FM 730 – Decatur Airport	Interchange
				FM 51 – Gainesville, Weatherford	Interchange
				Bus. US 380 west
Denton	​			FM 2622 south – Stony
	​			FM 156 – Krum, Ponder, Fort Worth	Interchange
	Denton			I-35 / US 380 Truck – Gainesville, Dallas	I-35 exit 469
				US 77 south / US 377 south (North Elm Street)	West end of US 377 south overlap (westbound)
				US 77 north (North Locust Street) to FM 428	West end of US 377 north overlap (eastbound)
				Loop 288 / US 380 Truck west	Interchange
	Cross Roads			US 377 north – Pilot Point	Interchange; east end of US 377 overlap
				FM 424 north – Aubrey
	Lincoln Park			FM 720 east – Oak Point, Little Elm
	Providence Village–Little Elm line			FM 2931 north – Providence Village
	Little Elm–Prosper line			FM 1385 north
	Frisco–Prosper line			FM 423 south – Frisco, Little Elm, The Colony
Collin	Frisco–Prosper line			To Dallas Parkway south / Dallas North Tollway
				SH 289 (Preston Road) / Bus. SH 289 north – Prosper, Frisco	Interchange
	Prosper–McKinney line			FM 2478 (Custer Road) – Prosper, McKinney, Plano
	McKinney			To Lake Forest Drive / FM 1461
				US 75 / SH 121 (North Central Expressway) – Sherman, Dallas	US 75 exit 41
				SH 5 (McDonald Street) – Melissa, Fairview
				FM 1827 north – New Hope
	Princeton			FM 982 south
				FM 75 north (South 4th Street)
	Farmersville			SH 78 – Lavon, Blue Ridge	Interchange
				Main Street	Interchange
	​			FM 547 south – Josephine
Hunt	​			FM 36 north – Merit	West end of FM 36 overlap
	​			Bus. US 380 east
	​			FM 36 south / County Road 1118 – Floyd, Caddo Mills	East end of FM 36 overlap
	​			Bus. US 380 west
	​			FM 903 north – Wagner
	Greenville			US 69 north / Spur 302 east – Greenville, Denison	West end of US 69 overlap
				SH 66 west – Caddo Mills
				SH 34 (Wesley Street) – Greenville, Terrell
				I-30 / US 67 / US 69 south – Emory, Texarkana, Dallas	Eastern terminus; east end of US 69 overlap; I-30 exit 94
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• U.S. Route 80
• U.S. Route 180
• U.S. Route 280

• Endpoints of US highways: U.S. Highway 380 and U.S. Highway 566

Browse numbered routes
← US 377	TX	→ US 385