State Route 599 (SR 599) is a 7.049-mile (11.344 km) state highway in Clark County, Nevada. The route follows Rancho Drive, a major arterial connecting downtown Las Vegas to the northwest part of the city. Much of SR 599 was previously designated as U.S. Route 95 (US 95) prior to completion of the Las Vegas Expressway. The route is also designated as U.S. Route 95 Business (US 95 Bus.).

SR 599 begins at the intersection of Rancho Drive and Redondo Avenue in the city of Las Vegas. From there, the route heads north along Rancho Drive to intersect the I-11/US 95 freeway (at exit 77). The highway continues heading northwest for several miles, briefly skirting the western edge of North Las Vegas and providing access to the North Las Vegas Airport. The route reaches its northern terminus at the end of Rancho Drive, at the interchange with I-11/US 95 north and Ann Road (at exits 90 and 91).

US 95 freeway signs for Rancho Drive designate the route as U.S. Route 95 Business, a distinction noted on many maps (including those published by the Nevada Department of Transportation (NDOT)). However, no business route signs are posted along the highway itself and relatively few SR 599 shields can be found on the route.

Rancho Drive originally carried State Route 5 from Bonanza Road (present–day State Route 579) northwest out of Las Vegas towards Tonopah—this destination contributed to the road's alternate name of Tonopah Highway. When US 95 was extended into Nevada in 1940, it was routed concurrently with SR 5 on Rancho Drive. The U.S. route remained on Rancho Drive until it was relocated onto the completed Las Vegas Expressway in the early 1980s. SR 599 was designated along the former US 95/SR 5 at this time, in accordance with the 1976 renumbering of Nevada's State Routes.

SR 599 lost mileage between 1996 and 2000. In 2006, the route was pending removal from the state highway system to be transferred to the City of Las Vegas for maintenance, but this has not happened as of January 2008. By October 2011, the southern terminus of SR 599 had been moved from Sahara Avenue to Redondo Avenue, shortening the overall mileage to the current length.

This section is missing mileposts for junctions. Please help by adding them.

The entire route is in Clark County.

Location	mi	km	Destinations	Notes
Las Vegas			Rancho Bel Air Drive and Redondo Avenue	Southern terminus of SR 599; Rancho Drive continues south on the former route of SR 599 south
			I-11 / US 95 (Oran K. Gragson Freeway, Veterans Memorial Highway south) to I-15 – Downtown Las Vegas, Tonopah, Reno, Los Angeles, Salt Lake City	Interchange; southern end of Veterans Memorial Highway concurrency; southern terminus of US 95 Business; I-11/US 95 exit 77
			Bonanza Road (SR 579 east)	Former US 95 south
Las Vegas–North Las Vegas line			Lake Mead Boulevard
			Decatur Boulevard
Las Vegas			Cheyenne Avenue (SR 574)
			Craig Road (SR 573)
			I-11 north / US 95 north (Veterans Memorial Highway north) / Ann Road – Tonopah, Reno	Interchange; northern end of Veterans Memorial Highway concurrency; northern terminus of SR 599 and US 95 Business; I-11/US 95 exits 90 and 91
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

RTC Transit Routes 106A, 106B and 119 function on this road.