The University of South Carolina Upstate (USC Upstate) is a public university in Valley Falls, South Carolina, with a Spartanburg postal address. Founded in 1967 and formerly known as University of South Carolina Spartanburg, the institution changed its name in the summer of 2004. It offers bachelor's, master's and doctoral degrees for students in the Upstate and surrounding areas. It is part of the University of South Carolina System and home to approximately 5,200 students and 340 full-time faculty. It is accredited by the Southern Association of Colleges and Schools.

After the Spartanburg General Hospital decided to discontinue its degree program for nurses, local politicians, led by G.B. Hodge, decided to create a separate university for the region. In 1967 the Spartanburg Regional Campus was opened as a two-year college with an initial enrollment of 177 students. Because of increased popularity, the school became a four-year institution in 1975 and was renamed as the University of South Carolina Spartanburg. During the following years, both the campus and the scope of the University expanded.

In the summer of 2004 USC's board of trustees voted to change the name to the University of South Carolina Upstate to better reflect its mission to educate the people of South Carolina's upstate region. It has become the largest educational provider in the University Center Greenville, a consortium of seven institutions of higher learning in Greenville, South Carolina and the immediate surrounding area.

• College of Arts, Social Science, and Humanities
• College of Science and Technology
• Mary Black College of Nursing
• George Dean Johnson Jr., College of Business and Economics
• College of Education, Human Performance, and Health

University of South Carolina Upstate has many clubs and organizations as well as academic teams whose main goals are the intellectual and interpersonal growth of students through community service and wide-ranging cultural activities.

There are several fraternities and sororities on campus.

University of South Carolina Upstate sponsors 15 collegiate teams known as the Spartans. The athletic department colors are green, white, and black. The teams compete in the Big South Conference and Division I of the NCAA. These sports are men's and women's basketball, men's and women's soccer, men's and women's golf, baseball, softball, track and field, cross country, and women's volleyball.

• Official website
• USC Upstate Athletics website