U.S. Route 60 (US 60) is an east–west United States Highway within Arizona. The highway runs for 369 miles (594 km) from a junction with Interstate 10 near Quartzsite to the New Mexico state line near Springerville. As it crosses the state, US 60 overlaps at various points: I-17, I-10, SR 77, SR 260, US 191, and US 180. Between Wickenburg and Phoenix, the route is known as Grand Avenue (or the Phoenix–Wickenburg Highway). From Tempe to Apache Junction, it is known as the Superstition Freeway.

The western terminus of US 60 is located at an interchange with I-10 near the community of Brenda east of Quartzite. It heads northeast from this junction to Vicksburg Junction where it curves towards the east. It continues to the east to Hope where it intersects SR 72. East of Hope, the highway briefly curves towards the north-northeast through the Granite Wash Pass before curving towards the northeast. It continues this direction until it reaches Aguila. The highway heads east to an intersection with SR 71 after passing through Aguila. US 60 continues towards the east until it reaches Wickenburg and an intersection with US 93. From Wickenburg, the highway heads towards the southeast towards Phoenix. It has an intersection with SR 74 in Morristown as it continues towards the southeast.

As US 60 enters the Phoenix metropolitan area, It intersects Loop 303 in Surprise where it becomes Grand Avenue as it continues southeast. It continues to a junction with Loop 101 (Agua Fria Freeway) in Peoria before heading through Glendale. The highway enters the Phoenix city limits and continues towards the southeast until it reaches an interchange with 27th Avenue near Thomas Road.

Improvements to the Grand Avenue portion of US 60, which were included in the Maricopa Association of Governments' 20-year Regional Transportation Plan, have been made. Among such improvements is the reducing of many of the busiest six-legged intersections to four-legged intersections by constructing overpasses, underpasses, and access roads.

After briefly heading south along 27th Avenue, US 60 turns left onto Thomas Road for 1⁄4 mile (0.40 km) until it reaches I-17. At I-17 the highway begins to run concurrently with I-17 towards the south. It passes through an I-10 interchange known as "The Stack." US 60 continues to run concurrent with I-17 around the Durango Curve and continues east until it again reaches I-10 at the interchange known as "The Split." US 60 begins to run concurrently towards the east with I-10 after the interchange. Along the freeway, US 60 passes along the south side of the airport and over a bridge traversing the Salt River. Once over the river, the freeway continues towards Tempe to an interchange with SR 143. The freeway curves back towards the south following the SR 143 interchange.

After the curve, I-10 and US 60 part ways in Tempe, with I-10 continuing towards the south and US 60 now heading east along the Superstition Freeway. The freeway continues towards the east to a second interchange with Loop 101 (Price Freeway).

The freeway enters Mesa city limits after the interchange as it continues towards the east to the SuperRedTan interchange with Loop 202. The freeway enters the city limits of Apache Junction in Pinal County as it continues eastbound. The freeway portion of the highway ends in Apache Junction as US 60 curves towards the southeast.

The highway continues towards the southeast passing through Gold Canyon to an interchange with SR 79 at Florence Junction. US 60 curves towards the east at this junction as it heads to Superior and an interchange with SR 177. From Superior the highway begins to head towards the northeast to Miami and Claypool. It continues to a junction with SR 188 before passing through Midland City and turning towards the south towards Globe. US 60 curves back towards the east in Globe and continues to an intersection with US 70 and SR 77. US 60 heads northeast from the intersection concurrent with SR 77. The two highways curve towards the north before curving back towards the northeast as they head towards Show Low. As the highway continues towards the northeast it enters the San Carlos Indian Reservation. Within the reservation, the highway goes through a series of hairpin turns as it enters the Salt River Canyon. After descending into the canyon, the highway passes over the Salt River and enters the Fort Apache Indian Reservation. The highway continues towards the northeast and enters Navajo County before reaching an intersection with SR 73. It continues northeast from this intersection to the city of Show Low.

In Show Low, US 60 intersects SR 260 and briefly runs concurrently with SR 260 as it heads northeast through the city. The concurrency with SR 77 also ends in Show Low as SR 77 heads north to Snowflake and US 60 continues towards the east. US 60 leaves the Show Low city limits and heads east to a junction with SR 61 which heads northeast towards Concho. US 60 continues east from this intersection before curving towards the southeast as it heads towards Springerville.

As it enters the Springerville city limits, it intersects and begins to run concurrently with US 180 and US 191. The three highways continue along the same alignment through Springerville, passing over the Little Colorado River. As the three highways continue through the city, they eventually split with US 180 and US 191 heading south towards Alpine and US 60 continuing towards the east. US 60 continues towards the east leaving the Springerville city limits and crossing over the state line into New Mexico.

State Route 74
Location	Ehrenberg to Wickenburg
Length	111.20 mi (178.96 km)
Existed	1927–1931

State Route 360
Location	Tempe to Apache Junction
Length	26.41 mi (42.50 km)
Existed	1970–1992

In 1927, what is now US 60 was signed as or roughly followed by SR 74 between the California border near Ehrenburg and Wickenburg, US 89 from Wickenburg to Florence Junction, US 80 from Phoenix to Florence Junction, US 180 from Florence Junction to Globe and US 70 between Springerville and the New Mexico border. The segment of highway between Springerville and Globe had not been constructed yet. US 60 was extended into Arizona on June 8, 1931, from its original western terminus at US 66 in Springfield, Missouri. While what is now US 60 was under construction between Globe and Springerville, US 60 was temporarily routed down SR 73 as US 60T through San Carlos and McNary. The current route through Show Low was completed sometime between 1935 and 1938. US 60 through Arizona has had far fewer major changes than some other U.S. routes, but one notable example is being replaced by Interstate 10 between Los Angeles, California, and the highway's current terminus near Quartzsite. (The Arizona section of this route was decommissioned in 1982.)

US 60 is now the only U.S. Route to serve Phoenix. US 70 (decommissioned 1969), US 80 (decommissioned 1977) and US 89 (decommissioned 1992) have all been truncated outside of Phoenix. The only other major change was being realigned from an "in-town" route along city arterials through Mesa, Tempe, and Phoenix to the old SR 360 alignment a few miles south and merging with I-10 and I-17 into Downtown Phoenix.

In 1949, the Pinto Creek Bridge won an Annual Award of Merit for being the "most beautiful steel bridge", given by the American Institute of Steel Construction.

In 1952, the Claypool Tunnel was bypassed by the Queen Creek Tunnel to the north, upgrading from a simple “hole in the rock”-type tunnel to a more modern tunnel.

In recent years, Arizona Department of Transportation (ADOT) has been working to widen and improve US 60 through the Metropolitan Phoenix area, as it is one of the area's principal freeways. Along the Superstition Freeway segment in the East Valley between I-10 and Loop 202, ADOT has completed its project of adding additional general purpose lanes (five total plus an HOV lane in each direction), adding auxiliary lanes between exits, improving sound barriers, replacing signs, improving lighting conditions, adding rubberized asphalt to reduce noise, adding variable message signs, installing cameras, and adding traffic sensors. A new partial interchange at Meridian Road, along the Maricopa–Pinal county line, opened in October 2015.