The U.S. Customs House and Post Office, also known as the Escambia County Courthouse, is a historic site in Pensacola, Florida. Built in 1887, it is located at 223 Palafox Place. On July 22, 1997, it was added to the U.S. National Register of Historic Places.

From 1885 to 1937, the Escambia County Courthouse was a building on the northeast corner of Palafox and Chase streets. In 1937 Escambia County, which needed more space, swapped its location for that of the U.S. Customs House and Post Office because the Federal Government, which by then had no more use for a customs house, needed a building site for a new U.S. Post Office and Courthouse. The Federal Government demolished the old county courthouse in 1938 and built its new building there. The county moved into the Blount Building until renovations were done on the old customs house and post office in 1938. The building, which is still called the county courthouse, is now part of the Escambia County Government Center, which includes the M. C. Blanchard Judicial Building, where the courts and clerk's offices are now located.

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• List of United States post offices

• Artel Gallery
• Escambia County listings at National Register of Historic Places
• Florida's Office of Cultural and Historical Programs
  • Escambia County listings
  • Escambia County Courthouse
• Florida's Historic Courthouses
• Florida's Historic Courthouses by Hampton Dunn (ISBN 0-9653759-5-1)